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Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome.
Hum Reprod. 2009 Jul; 24(7):1726-31.HR

Abstract

BACKGROUND

Metabolic disturbances are common features of polycystic ovary syndrome (PCOS), which possibly enhance the risk of cardiovascular disease. The aim of this study was to assess the accuracy of lipid accumulation product (LAP) index as a marker of cardiovascular risk in PCOS patients.

METHODS

Case-control study including 51 PCOS patients aged between 14 and 35 years and 44 body mass index (BMI) and age-matched controls. Measures included the LAP index, homeostasis model assessment (HOMA) index, glucose tolerance and plasma hormones, cholesterols and triglycerides.

RESULTS

LAP index was positively correlated with HOMA index in all subjects (r = 0.70; P < 0.001). Waist circumference (WC) (P = 0.002), HOMA index (P < 0.001) and LAP index (P = 0.035) were higher in PCOS patients than controls. On receiver operating characteristic curve analysis, an LAP index of 34.5 (sensitivity: 84%; specificity 79%) showed a better performance than non-high-density lipoprotein cholesterol, WC or BMI to identify insulin resistance (IR) in all subjects. In PCOS patients, the positive and negative predictive values for LAP > or = 34.5 were 91 and 74%, respectively, compared with 73 and 61%, respectively, for WC > or =80 cm, and 43 and 20%, respectively, for WC > or =88 cm. CONCLUSIONS We have confirmed that IR is more common in PCOS than BMI-matched control women. Furthermore, the LAP index, an easily obtainable measure, is associated with HOMA index and an LAP > or = 34.5 is an additional risk factor for cardiovascular disease in PCOS patients.

Authors+Show Affiliations

Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19329517

Citation

Wiltgen, D, et al. "Lipid Accumulation Product Index: a Reliable Marker of Cardiovascular Risk in Polycystic Ovary Syndrome." Human Reproduction (Oxford, England), vol. 24, no. 7, 2009, pp. 1726-31.
Wiltgen D, Benedetto IG, Mastella LS, et al. Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome. Hum Reprod. 2009;24(7):1726-31.
Wiltgen, D., Benedetto, I. G., Mastella, L. S., & Spritzer, P. M. (2009). Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome. Human Reproduction (Oxford, England), 24(7), 1726-31. https://doi.org/10.1093/humrep/dep072
Wiltgen D, et al. Lipid Accumulation Product Index: a Reliable Marker of Cardiovascular Risk in Polycystic Ovary Syndrome. Hum Reprod. 2009;24(7):1726-31. PubMed PMID: 19329517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome. AU - Wiltgen,D, AU - Benedetto,I G, AU - Mastella,L S, AU - Spritzer,P M, Y1 - 2009/03/27/ PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/8/27/medline SP - 1726 EP - 31 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 24 IS - 7 N2 - BACKGROUND: Metabolic disturbances are common features of polycystic ovary syndrome (PCOS), which possibly enhance the risk of cardiovascular disease. The aim of this study was to assess the accuracy of lipid accumulation product (LAP) index as a marker of cardiovascular risk in PCOS patients. METHODS: Case-control study including 51 PCOS patients aged between 14 and 35 years and 44 body mass index (BMI) and age-matched controls. Measures included the LAP index, homeostasis model assessment (HOMA) index, glucose tolerance and plasma hormones, cholesterols and triglycerides. RESULTS: LAP index was positively correlated with HOMA index in all subjects (r = 0.70; P < 0.001). Waist circumference (WC) (P = 0.002), HOMA index (P < 0.001) and LAP index (P = 0.035) were higher in PCOS patients than controls. On receiver operating characteristic curve analysis, an LAP index of 34.5 (sensitivity: 84%; specificity 79%) showed a better performance than non-high-density lipoprotein cholesterol, WC or BMI to identify insulin resistance (IR) in all subjects. In PCOS patients, the positive and negative predictive values for LAP > or = 34.5 were 91 and 74%, respectively, compared with 73 and 61%, respectively, for WC > or =80 cm, and 43 and 20%, respectively, for WC > or =88 cm. CONCLUSIONS We have confirmed that IR is more common in PCOS than BMI-matched control women. Furthermore, the LAP index, an easily obtainable measure, is associated with HOMA index and an LAP > or = 34.5 is an additional risk factor for cardiovascular disease in PCOS patients. SN - 1460-2350 UR - https://www.unboundmedicine.com/medline/citation/19329517/Lipid_accumulation_product_index:_a_reliable_marker_of_cardiovascular_risk_in_polycystic_ovary_syndrome_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dep072 DB - PRIME DP - Unbound Medicine ER -