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[Chronic kidney disease (CKD) and bone. Impact of diabetes mellitus on the development of CKD-MBD].
Clin Calcium. 2009 Apr; 19(4):502-7.CC

Abstract

Chronic kidney disease-mineral and bone disorder (CKD-MBD) develops as renal function deteriorates. The presence of diabetes mellitus as comorbidity modulates the severity of CKD-MBD. The prevalence of vascular calcification, which becomes higher in diabetic CKD patients than in non-CKD counterparts, increases cardiovascular mortality in diabetic patients. The main factor which causes vascular calcification in diabetic CKD patients is poor glycemic control, in contrast to hyperphosphatemia in non-diabetic CKD patients. Diabetes directly impairs osetoblasts to decrease bone mass, suppresses bone turnover to impair bone quality by impairing secretion of parathyroid hormone and increase AGE-modification of bone collagen. Therefore, therapeutic regimens for CKD-MBD should be considered specifically for diabetic CKD patients since the mode of its development differs between diabetic and non-diabetic CKD patients.

Authors+Show Affiliations

Endocrinology and Molecular Medicine, Department of Metabolism, Osaka City University Graduate School of Medicine.

Pub Type(s)

Journal Article
Review

Language

jpn

PubMed ID

19329828

Citation

Inaba, Masaaki. "[Chronic Kidney Disease (CKD) and Bone. Impact of Diabetes Mellitus On the Development of CKD-MBD]." Clinical Calcium, vol. 19, no. 4, 2009, pp. 502-7.
Inaba M. [Chronic kidney disease (CKD) and bone. Impact of diabetes mellitus on the development of CKD-MBD]. Clin Calcium. 2009;19(4):502-7.
Inaba, M. (2009). [Chronic kidney disease (CKD) and bone. Impact of diabetes mellitus on the development of CKD-MBD]. Clinical Calcium, 19(4), 502-7. https://doi.org/CliCa0904502507
Inaba M. [Chronic Kidney Disease (CKD) and Bone. Impact of Diabetes Mellitus On the Development of CKD-MBD]. Clin Calcium. 2009;19(4):502-7. PubMed PMID: 19329828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chronic kidney disease (CKD) and bone. Impact of diabetes mellitus on the development of CKD-MBD]. A1 - Inaba,Masaaki, PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/6/26/medline SP - 502 EP - 7 JF - Clinical calcium JO - Clin Calcium VL - 19 IS - 4 N2 - Chronic kidney disease-mineral and bone disorder (CKD-MBD) develops as renal function deteriorates. The presence of diabetes mellitus as comorbidity modulates the severity of CKD-MBD. The prevalence of vascular calcification, which becomes higher in diabetic CKD patients than in non-CKD counterparts, increases cardiovascular mortality in diabetic patients. The main factor which causes vascular calcification in diabetic CKD patients is poor glycemic control, in contrast to hyperphosphatemia in non-diabetic CKD patients. Diabetes directly impairs osetoblasts to decrease bone mass, suppresses bone turnover to impair bone quality by impairing secretion of parathyroid hormone and increase AGE-modification of bone collagen. Therefore, therapeutic regimens for CKD-MBD should be considered specifically for diabetic CKD patients since the mode of its development differs between diabetic and non-diabetic CKD patients. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/19329828/[Chronic_kidney_disease__CKD__and_bone__Impact_of_diabetes_mellitus_on_the_development_of_CKD_MBD]_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -