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Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children.
J Pediatr Gastroenterol Nutr 2009; 48(4):431-6JP

Abstract

OBJECTIVE

To determine the effectiveness of Lactobacillus GG (LGG) in children with Helicobacter pylori infection undergoing eradication therapy.

MATERIALS AND METHODS

We conducted a double-blind, placebo-controlled, randomized trial comparing a 7-day, triple eradication regimen consisting of 2 antibiotics (amoxicillin tablets, 25 mg/kg twice per day, and clarithromycin tablets, 10 mg/kg twice per day) plus a proton pump inhibitor (omeprazole capsules, 0.5 mg/kg twice per day) supplemented with LGG (109 colony-forming units) or placebo in 83 children with H pylori infection confirmed by 2 of 3 tests (13C-urea breath test, histopathology, rapid urease test). The primary outcome measure was the H pylori eradication rate. The secondary outcome measure was the proportion of patients who experienced therapy-related adverse effects during anti-H pylori treatment.

RESULTS

The groups did not differ with respect to H pylori eradication rates. Of the 34 children in the LGG group, 23 (69%) experienced eradication, compared with 22 of 32 children (68%) in the placebo group (RR 0.98, 95% CI 0.7-1.4). The groups did not differ with respect to adverse effects.

CONCLUSIONS

In children with H pylori infection, supplementation of standard triple therapy with LGG did not significantly alter the eradication rate or side effects.

Authors+Show Affiliations

2nd Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland. hania@ipgate.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

19330931

Citation

Szajewska, Hania, et al. "Randomized, Double-blind, Placebo-controlled Trial: Effect of Lactobacillus GG Supplementation On Helicobacter Pylori Eradication Rates and Side Effects During Treatment in Children." Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 4, 2009, pp. 431-6.
Szajewska H, Albrecht P, Topczewska-Cabanek A. Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. J Pediatr Gastroenterol Nutr. 2009;48(4):431-6.
Szajewska, H., Albrecht, P., & Topczewska-Cabanek, A. (2009). Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. Journal of Pediatric Gastroenterology and Nutrition, 48(4), pp. 431-6.
Szajewska H, Albrecht P, Topczewska-Cabanek A. Randomized, Double-blind, Placebo-controlled Trial: Effect of Lactobacillus GG Supplementation On Helicobacter Pylori Eradication Rates and Side Effects During Treatment in Children. J Pediatr Gastroenterol Nutr. 2009;48(4):431-6. PubMed PMID: 19330931.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. AU - Szajewska,Hania, AU - Albrecht,Piotr, AU - Topczewska-Cabanek,Agnieszka, PY - 2009/3/31/entrez PY - 2009/3/31/pubmed PY - 2009/7/29/medline SP - 431 EP - 6 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 48 IS - 4 N2 - OBJECTIVE: To determine the effectiveness of Lactobacillus GG (LGG) in children with Helicobacter pylori infection undergoing eradication therapy. MATERIALS AND METHODS: We conducted a double-blind, placebo-controlled, randomized trial comparing a 7-day, triple eradication regimen consisting of 2 antibiotics (amoxicillin tablets, 25 mg/kg twice per day, and clarithromycin tablets, 10 mg/kg twice per day) plus a proton pump inhibitor (omeprazole capsules, 0.5 mg/kg twice per day) supplemented with LGG (109 colony-forming units) or placebo in 83 children with H pylori infection confirmed by 2 of 3 tests (13C-urea breath test, histopathology, rapid urease test). The primary outcome measure was the H pylori eradication rate. The secondary outcome measure was the proportion of patients who experienced therapy-related adverse effects during anti-H pylori treatment. RESULTS: The groups did not differ with respect to H pylori eradication rates. Of the 34 children in the LGG group, 23 (69%) experienced eradication, compared with 22 of 32 children (68%) in the placebo group (RR 0.98, 95% CI 0.7-1.4). The groups did not differ with respect to adverse effects. CONCLUSIONS: In children with H pylori infection, supplementation of standard triple therapy with LGG did not significantly alter the eradication rate or side effects. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/19330931/Randomized_double_blind_placebo_controlled_trial:_effect_of_lactobacillus_GG_supplementation_on_Helicobacter_pylori_eradication_rates_and_side_effects_during_treatment_in_children_ L2 - http://Insights.ovid.com/pubmed?pmid=19330931 DB - PRIME DP - Unbound Medicine ER -