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Prospects for nanomedicine in treating age-related macular degeneration.
Nanomedicine (Lond). 2009 Apr; 4(3):341-52.N

Abstract

Polyion complex (PIC) micelles have a size range of tens of nanometers formed through electrostatic interaction. In experimental choroidal neovascularization (CNV) in rats, the PIC micelle accumulates to the CNV lesions and is retained. PIC micelles can be used for effective drug delivery to CNV. A novel dendritic photosensitizer encapsulated by a polymeric-micelle formulation was employed for an effective photodynamic therapy for age-related macular degeneration. With its highly selective accumulation on experimental CNV lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. Gene therapy is a promising approach to treat age-related macular degeneration. A ternary complex, composed of a core containing DNA packaged with cationic peptides and enveloped in the anionic dendrimer phthalocyanine, has been developed, which provides the photosensitizing action. Subconjunctival injection of the ternary complex followed by laser irradiation resulted in transgene expression only in the laser-irradiated site in rats.

Authors+Show Affiliations

Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. tamaki-tky@umin.ac.jp

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19331541

Citation

Tamaki, Yasuhiro. "Prospects for Nanomedicine in Treating Age-related Macular Degeneration." Nanomedicine (London, England), vol. 4, no. 3, 2009, pp. 341-52.
Tamaki Y. Prospects for nanomedicine in treating age-related macular degeneration. Nanomedicine (Lond). 2009;4(3):341-52.
Tamaki, Y. (2009). Prospects for nanomedicine in treating age-related macular degeneration. Nanomedicine (London, England), 4(3), 341-52. https://doi.org/10.2217/nnm.09.10
Tamaki Y. Prospects for Nanomedicine in Treating Age-related Macular Degeneration. Nanomedicine (Lond). 2009;4(3):341-52. PubMed PMID: 19331541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospects for nanomedicine in treating age-related macular degeneration. A1 - Tamaki,Yasuhiro, PY - 2009/4/1/entrez PY - 2009/4/1/pubmed PY - 2009/6/3/medline SP - 341 EP - 52 JF - Nanomedicine (London, England) JO - Nanomedicine (Lond) VL - 4 IS - 3 N2 - Polyion complex (PIC) micelles have a size range of tens of nanometers formed through electrostatic interaction. In experimental choroidal neovascularization (CNV) in rats, the PIC micelle accumulates to the CNV lesions and is retained. PIC micelles can be used for effective drug delivery to CNV. A novel dendritic photosensitizer encapsulated by a polymeric-micelle formulation was employed for an effective photodynamic therapy for age-related macular degeneration. With its highly selective accumulation on experimental CNV lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. Gene therapy is a promising approach to treat age-related macular degeneration. A ternary complex, composed of a core containing DNA packaged with cationic peptides and enveloped in the anionic dendrimer phthalocyanine, has been developed, which provides the photosensitizing action. Subconjunctival injection of the ternary complex followed by laser irradiation resulted in transgene expression only in the laser-irradiated site in rats. SN - 1748-6963 UR - https://www.unboundmedicine.com/medline/citation/19331541/Prospects_for_nanomedicine_in_treating_age_related_macular_degeneration_ L2 - https://www.futuremedicine.com/doi/10.2217/nnm.09.10?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -