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Rotavirus disease and prevention through vaccination.
Pediatr Infect Dis J 2009; 28(4):355-62, quiz 363-4PI

Abstract

Rotavirus is the most common cause of acute infectious gastroenteritis in children and is associated with substantial morbidity in the United States and morbidity and mortality in the developing world. Two orally administered vaccines, a live bovine reassortant vaccine (RV5; licensed in 2006) and a live attenuated human vaccine (RV1; licensed in 2008), are now being used in a universal infant vaccination program in the United States. There is already ecologic evidence and data from post-licensure effectiveness studies that this program will be an unequivocal success in reducing the impact of rotavirus disease. This overview presents the structure, pathogenesis, and mechanisms of natural immunity to rotavirus, key concepts in understanding the rationale behind vaccine-induced protection. The history of rotavirus vaccine development is also included, along with a discussion of the safety, efficacy, and recommended use of the approved vaccines.

Authors+Show Affiliations

Division of Pediatric Infectious Diseases, University of Louisville School of Medicine, Louisville, KY, USA. gsmars01@louisville.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19333083

Citation

Marshall, Gary S.. "Rotavirus Disease and Prevention Through Vaccination." The Pediatric Infectious Disease Journal, vol. 28, no. 4, 2009, pp. 355-62, quiz 363-4.
Marshall GS. Rotavirus disease and prevention through vaccination. Pediatr Infect Dis J. 2009;28(4):355-62, quiz 363-4.
Marshall, G. S. (2009). Rotavirus disease and prevention through vaccination. The Pediatric Infectious Disease Journal, 28(4), pp. 355-62, quiz 363-4. doi:10.1097/INF.0b013e318199494a.
Marshall GS. Rotavirus Disease and Prevention Through Vaccination. Pediatr Infect Dis J. 2009;28(4):355-62, quiz 363-4. PubMed PMID: 19333083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rotavirus disease and prevention through vaccination. A1 - Marshall,Gary S, PY - 2009/4/1/entrez PY - 2009/4/1/pubmed PY - 2009/5/21/medline SP - 355-62, quiz 363-4 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 28 IS - 4 N2 - Rotavirus is the most common cause of acute infectious gastroenteritis in children and is associated with substantial morbidity in the United States and morbidity and mortality in the developing world. Two orally administered vaccines, a live bovine reassortant vaccine (RV5; licensed in 2006) and a live attenuated human vaccine (RV1; licensed in 2008), are now being used in a universal infant vaccination program in the United States. There is already ecologic evidence and data from post-licensure effectiveness studies that this program will be an unequivocal success in reducing the impact of rotavirus disease. This overview presents the structure, pathogenesis, and mechanisms of natural immunity to rotavirus, key concepts in understanding the rationale behind vaccine-induced protection. The history of rotavirus vaccine development is also included, along with a discussion of the safety, efficacy, and recommended use of the approved vaccines. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/19333083/Rotavirus_disease_and_prevention_through_vaccination_ L2 - http://dx.doi.org/10.1097/INF.0b013e318199494a DB - PRIME DP - Unbound Medicine ER -