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Severity of disease, rather than xerosis, correlates with pruritus in patients with atopic dermatitis.
Int J Dermatol 2009; 48(4):374-8IJ

Abstract

BACKGROUND

Atopic dermatitis (AD) is a chronic, relapsing skin disease characterized by xerosis and pruritus. As pruritus is an unpleasant sensation and the associated scratching aggravates the skin eruption considerably, it is important to control this symptom when treating AD. Dry skin is generally considered to be a potential cause of pruritus in xerotic skin diseases, but a clear correlation between pruritus and atopic xerosis has not been demonstrated. Aim To examine the contribution of atopic xerosis to the development of pruritus in AD.

METHODS

Twenty-two patients with AD (12 males and 10 females; mean age, 27.5 years) were examined. Xerosis and the severity of disease were evaluated using the Objective Severity Assessment of Atopic Dermatitis (OSAAD) and the SCORing Atopic Dermatitis (SCORAD) index, respectively. A modified SCORAD index was calculated by removing the symptoms potentially associated with pruritus (intensity of itching and insomnia) from the standard SCORAD index. Pruritus was evaluated using both a visual analog scale and the Verbal Itch Score.

RESULTS

The severity of AD (modified SCORAD index) correlated better than atopic xerosis (OSAAD score) with both pruritus scores, possibly indicating that the use of appropriate anti-inflammatory agents may be helpful in controlling pruritus as well as skin eruption in AD.

CONCLUSION

Our data suggest that the severity of disease (or skin inflammation) provides a greater contribution than xerosis to the development of pruritus in AD.

Authors+Show Affiliations

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19335422

Citation

Hachisuka, Junichi, et al. "Severity of Disease, Rather Than Xerosis, Correlates With Pruritus in Patients With Atopic Dermatitis." International Journal of Dermatology, vol. 48, no. 4, 2009, pp. 374-8.
Hachisuka J, Takeuchi S, Kido M, et al. Severity of disease, rather than xerosis, correlates with pruritus in patients with atopic dermatitis. Int J Dermatol. 2009;48(4):374-8.
Hachisuka, J., Takeuchi, S., Kido, M., Fukiwake, N., & Furue, M. (2009). Severity of disease, rather than xerosis, correlates with pruritus in patients with atopic dermatitis. International Journal of Dermatology, 48(4), pp. 374-8. doi:10.1111/j.1365-4632.2009.03906.x.
Hachisuka J, et al. Severity of Disease, Rather Than Xerosis, Correlates With Pruritus in Patients With Atopic Dermatitis. Int J Dermatol. 2009;48(4):374-8. PubMed PMID: 19335422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severity of disease, rather than xerosis, correlates with pruritus in patients with atopic dermatitis. AU - Hachisuka,Junichi, AU - Takeuchi,Satoshi, AU - Kido,Makiko, AU - Fukiwake,Noriko, AU - Furue,Masutaka, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/7/14/medline SP - 374 EP - 8 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 48 IS - 4 N2 - BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing skin disease characterized by xerosis and pruritus. As pruritus is an unpleasant sensation and the associated scratching aggravates the skin eruption considerably, it is important to control this symptom when treating AD. Dry skin is generally considered to be a potential cause of pruritus in xerotic skin diseases, but a clear correlation between pruritus and atopic xerosis has not been demonstrated. Aim To examine the contribution of atopic xerosis to the development of pruritus in AD. METHODS: Twenty-two patients with AD (12 males and 10 females; mean age, 27.5 years) were examined. Xerosis and the severity of disease were evaluated using the Objective Severity Assessment of Atopic Dermatitis (OSAAD) and the SCORing Atopic Dermatitis (SCORAD) index, respectively. A modified SCORAD index was calculated by removing the symptoms potentially associated with pruritus (intensity of itching and insomnia) from the standard SCORAD index. Pruritus was evaluated using both a visual analog scale and the Verbal Itch Score. RESULTS: The severity of AD (modified SCORAD index) correlated better than atopic xerosis (OSAAD score) with both pruritus scores, possibly indicating that the use of appropriate anti-inflammatory agents may be helpful in controlling pruritus as well as skin eruption in AD. CONCLUSION: Our data suggest that the severity of disease (or skin inflammation) provides a greater contribution than xerosis to the development of pruritus in AD. SN - 1365-4632 UR - https://www.unboundmedicine.com/medline/citation/19335422/Severity_of_disease_rather_than_xerosis_correlates_with_pruritus_in_patients_with_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-4632.2009.03906.x DB - PRIME DP - Unbound Medicine ER -