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Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort.
J Peripher Nerv Syst 2009; 14(1):1-13JP

Abstract

We evaluated the associations between glycemic therapies and prevalence of diabetic peripheral neuropathy (DPN) at baseline among participants in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial on medical and revascularization therapies for coronary artery disease (CAD) and on insulin-sensitizing vs. insulin-providing treatments for diabetes. A total of 2,368 patients with type 2 diabetes and CAD was evaluated. DPN was defined as clinical examination score >2 using the Michigan Neuropathy Screening Instrument (MNSI). DPN odds ratios across different groups of glycemic therapy were evaluated by multiple logistic regression adjusted for multiple covariates including age, sex, hemoglobin A1c (HbA1c), and diabetes duration. Fifty-one percent of BARI 2D subjects with valid baseline characteristics and MNSI scores had DPN. After adjusting for all variables, use of insulin was significantly associated with DPN (OR = 1.57, 95% CI: 1.15-2.13). Patients on sulfonylurea (SU) or combination of SU/metformin (Met)/thiazolidinediones (TZD) had marginally higher rates of DPN than the Met/TZD group. This cross-sectional study in a cohort of patients with type 2 diabetes and CAD showed association of insulin use with higher DPN prevalence, independent of disease duration, glycemic control, and other characteristics. The causality between a glycemic control strategy and DPN cannot be evaluated in this cross-sectional study, but continued assessment of DPN and randomized therapies in BARI 2D trial may provide further explanations on the development of DPN.

Authors+Show Affiliations

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. rpbusui@umich.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19335534

Citation

Pop-Busui, Rodica, et al. "Prevalence of Diabetic Peripheral Neuropathy and Relation to Glycemic Control Therapies at Baseline in the BARI 2D Cohort." Journal of the Peripheral Nervous System : JPNS, vol. 14, no. 1, 2009, pp. 1-13.
Pop-Busui R, Lu J, Lopes N, et al. Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. J Peripher Nerv Syst. 2009;14(1):1-13.
Pop-Busui, R., Lu, J., Lopes, N., & Jones, T. L. (2009). Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. Journal of the Peripheral Nervous System : JPNS, 14(1), pp. 1-13. doi:10.1111/j.1529-8027.2009.00200.x.
Pop-Busui R, et al. Prevalence of Diabetic Peripheral Neuropathy and Relation to Glycemic Control Therapies at Baseline in the BARI 2D Cohort. J Peripher Nerv Syst. 2009;14(1):1-13. PubMed PMID: 19335534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. AU - Pop-Busui,Rodica, AU - Lu,Jiang, AU - Lopes,Neuza, AU - Jones,Teresa L Z, AU - ,, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/7/28/medline SP - 1 EP - 13 JF - Journal of the peripheral nervous system : JPNS JO - J. Peripher. Nerv. Syst. VL - 14 IS - 1 N2 - We evaluated the associations between glycemic therapies and prevalence of diabetic peripheral neuropathy (DPN) at baseline among participants in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial on medical and revascularization therapies for coronary artery disease (CAD) and on insulin-sensitizing vs. insulin-providing treatments for diabetes. A total of 2,368 patients with type 2 diabetes and CAD was evaluated. DPN was defined as clinical examination score >2 using the Michigan Neuropathy Screening Instrument (MNSI). DPN odds ratios across different groups of glycemic therapy were evaluated by multiple logistic regression adjusted for multiple covariates including age, sex, hemoglobin A1c (HbA1c), and diabetes duration. Fifty-one percent of BARI 2D subjects with valid baseline characteristics and MNSI scores had DPN. After adjusting for all variables, use of insulin was significantly associated with DPN (OR = 1.57, 95% CI: 1.15-2.13). Patients on sulfonylurea (SU) or combination of SU/metformin (Met)/thiazolidinediones (TZD) had marginally higher rates of DPN than the Met/TZD group. This cross-sectional study in a cohort of patients with type 2 diabetes and CAD showed association of insulin use with higher DPN prevalence, independent of disease duration, glycemic control, and other characteristics. The causality between a glycemic control strategy and DPN cannot be evaluated in this cross-sectional study, but continued assessment of DPN and randomized therapies in BARI 2D trial may provide further explanations on the development of DPN. SN - 1529-8027 UR - https://www.unboundmedicine.com/medline/citation/19335534/Prevalence_of_diabetic_peripheral_neuropathy_and_relation_to_glycemic_control_therapies_at_baseline_in_the_BARI_2D_cohort_ L2 - https://doi.org/10.1111/j.1529-8027.2009.00200.x DB - PRIME DP - Unbound Medicine ER -