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Psychopathological changes and quality of life in hepatitis C virus-infected, opioid-dependent patients during maintenance therapy.
Addiction. 2009 Apr; 104(4):630-40.A

Abstract

AIMS

To examine among maintenance patients (methadone or buprenorphine) with and without hepatitis C virus (HCV) infection (i) the frequency of psychopathological symptoms at baseline and 1-year follow-up; (ii) the association between antiviral interferon (IFN) treatment and psychopathological symptoms; and (iii) to explore whether IFN therapy has an effect on 1-year outcome of maintenance treatment.

DESIGN

Naturalistic prospective longitudinal cohort design.

SETTING

A total of 223 substitution centres in Germany.

PARTICIPANTS

A nationally representative sample of 2414 maintenance patients, namely 800 without and 1614 with HCV infection, of whom 122 received IFN therapy.

MEASURES

HCV infection (HCV+/HCV-), IFN (IFN+/IFN-) treatment status and clinical measures. Diagnostic status and severity (rated by clinician), psychopathology (BSI--Brief Symptom Inventory) and quality of life (EQ-5D--EuroQol Group questionnaire).

FINDINGS

HCV+ patients revealed indications for a moderately increased psychopathological burden and poorer quality of life at baseline and follow-up compared to HCV- patients. HCV+ patients showed a marked deterioration over time only in the BSI subscale somatization (P = 0.002), and the frequency of sleep disorders almost doubled over time (12.8% at baseline; 24.1% at follow-up; P < 0.01). IFN treatment, received by 10% of HCV+ patients, did not impair efficacy or tolerability of maintenance therapy and was associated overall with neither increased psychopathological burden nor reduced quality of life.

CONCLUSIONS

Findings suggest no increased risk among HCV+ patients on maintenance therapy for depressive or other psychopathological syndromes. In our patient sample, IFN treatment was not associated with increased psychopathological burden, reduced quality of life or poorer tolerability and efficacy of maintenance treatment.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany. arne.schaefer@mail.uni-wuerzburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19335661

Citation

Schäfer, Arne, et al. "Psychopathological Changes and Quality of Life in Hepatitis C Virus-infected, Opioid-dependent Patients During Maintenance Therapy." Addiction (Abingdon, England), vol. 104, no. 4, 2009, pp. 630-40.
Schäfer A, Wittchen HU, Backmund M, et al. Psychopathological changes and quality of life in hepatitis C virus-infected, opioid-dependent patients during maintenance therapy. Addiction. 2009;104(4):630-40.
Schäfer, A., Wittchen, H. U., Backmund, M., Soyka, M., Gölz, J., Siegert, J., Schäfer, M., Tretter, F., & Kraus, M. R. (2009). Psychopathological changes and quality of life in hepatitis C virus-infected, opioid-dependent patients during maintenance therapy. Addiction (Abingdon, England), 104(4), 630-40. https://doi.org/10.1111/j.1360-0443.2009.02509.x
Schäfer A, et al. Psychopathological Changes and Quality of Life in Hepatitis C Virus-infected, Opioid-dependent Patients During Maintenance Therapy. Addiction. 2009;104(4):630-40. PubMed PMID: 19335661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychopathological changes and quality of life in hepatitis C virus-infected, opioid-dependent patients during maintenance therapy. AU - Schäfer,Arne, AU - Wittchen,Hans-Ulrich, AU - Backmund,Markus, AU - Soyka,Michael, AU - Gölz,Jörg, AU - Siegert,Jens, AU - Schäfer,Martin, AU - Tretter,Felix, AU - Kraus,Michael R, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/7/2/medline SP - 630 EP - 40 JF - Addiction (Abingdon, England) JO - Addiction VL - 104 IS - 4 N2 - AIMS: To examine among maintenance patients (methadone or buprenorphine) with and without hepatitis C virus (HCV) infection (i) the frequency of psychopathological symptoms at baseline and 1-year follow-up; (ii) the association between antiviral interferon (IFN) treatment and psychopathological symptoms; and (iii) to explore whether IFN therapy has an effect on 1-year outcome of maintenance treatment. DESIGN: Naturalistic prospective longitudinal cohort design. SETTING: A total of 223 substitution centres in Germany. PARTICIPANTS: A nationally representative sample of 2414 maintenance patients, namely 800 without and 1614 with HCV infection, of whom 122 received IFN therapy. MEASURES: HCV infection (HCV+/HCV-), IFN (IFN+/IFN-) treatment status and clinical measures. Diagnostic status and severity (rated by clinician), psychopathology (BSI--Brief Symptom Inventory) and quality of life (EQ-5D--EuroQol Group questionnaire). FINDINGS: HCV+ patients revealed indications for a moderately increased psychopathological burden and poorer quality of life at baseline and follow-up compared to HCV- patients. HCV+ patients showed a marked deterioration over time only in the BSI subscale somatization (P = 0.002), and the frequency of sleep disorders almost doubled over time (12.8% at baseline; 24.1% at follow-up; P < 0.01). IFN treatment, received by 10% of HCV+ patients, did not impair efficacy or tolerability of maintenance therapy and was associated overall with neither increased psychopathological burden nor reduced quality of life. CONCLUSIONS: Findings suggest no increased risk among HCV+ patients on maintenance therapy for depressive or other psychopathological syndromes. In our patient sample, IFN treatment was not associated with increased psychopathological burden, reduced quality of life or poorer tolerability and efficacy of maintenance treatment. SN - 1360-0443 UR - https://www.unboundmedicine.com/medline/citation/19335661/Psychopathological_changes_and_quality_of_life_in_hepatitis_C_virus_infected_opioid_dependent_patients_during_maintenance_therapy_ L2 - https://doi.org/10.1111/j.1360-0443.2009.02509.x DB - PRIME DP - Unbound Medicine ER -