Tags

Type your tag names separated by a space and hit enter

Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine.
Pediatrics. 2009 Apr; 123(4):e653-60.Ped

Abstract

OBJECTIVE

The aim of this study was to investigate the prevalence and possible association of inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine.

METHODS

We performed genotypic analysis for factor V G1691A, factor II G20210A, methylenetetrahydrofolate reductase C677T, and 4 common platelet glycoprotein polymorphisms (human platelet alloantigen-1, -2, -3, and -5) in 150 children <18 years of age with established diagnoses of stroke, transient ischemic attack, or migraine. Children were classified into 5 groups, namely, childhood arterial ischemic stroke (N = 33), perinatal arterial ischemic stroke (N = 26), hemorrhagic stroke (N = 20), transient ischemic attack (N = 36), and migraine (N = 35). The control group consisted of 112 children < or =18 years of age from the same geographical region who had no history of neurologic or thromboembolic diseases.

RESULTS

Heterozygosity for factor V G1691A was associated with approximately sevenfold increased risk for arterial ischemic stroke, perinatal arterial ischemic stroke, and transient ischemic attack. Increased risk for transient ischemic attack was found in carriers of the human platelet alloantigen-2b allele, human platelet alloantigen-5a/b genotype, and combined human platelet alloantigen-2b and human platelet alloantigen-5b genotype. The presence of the human platelet alloantigen-2b allele was associated with a 2.23-fold increased risk for migraine, whereas carriers of the human platelet alloantigen-3b allele had a lower risk for arterial ischemic stroke than did carriers of the human platelet alloantigen-3a allele.

CONCLUSIONS

Factor V G1691A has an important role in susceptibility to arterial ischemic stroke, both in the perinatal/neonatal period and in childhood, as well as transient ischemic attacks. A minor impact of human platelet alloantigen polymorphisms suggests that platelet glycoprotein polymorphisms may increase the risk of transient ischemic attacks and migraine, but this should be confirmed in larger studies.

Authors+Show Affiliations

Clinical Institute of Laboratory Diagnosis, Clinical Hospital Center Zagreb, Zagreb University School of Medicine, Kispaticeva 12, Zagreb 10000, Croatia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19336355

Citation

Herak, Désirée Coen, et al. "Inherited Prothrombotic Risk Factors in Children With Stroke, Transient Ischemic Attack, or Migraine." Pediatrics, vol. 123, no. 4, 2009, pp. e653-60.
Herak DC, Antolic MR, Krleza JL, et al. Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. Pediatrics. 2009;123(4):e653-60.
Herak, D. C., Antolic, M. R., Krleza, J. L., Pavic, M., Dodig, S., Duranovic, V., Brkic, A. B., & Zadro, R. (2009). Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. Pediatrics, 123(4), e653-60. https://doi.org/10.1542/peds.2007-3737
Herak DC, et al. Inherited Prothrombotic Risk Factors in Children With Stroke, Transient Ischemic Attack, or Migraine. Pediatrics. 2009;123(4):e653-60. PubMed PMID: 19336355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. AU - Herak,Désirée Coen, AU - Antolic,Margareta Radic, AU - Krleza,Jasna Lenicek, AU - Pavic,Marina, AU - Dodig,Slavica, AU - Duranovic,Vlasta, AU - Brkic,Anica Basnec, AU - Zadro,Renata, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/4/29/medline SP - e653 EP - 60 JF - Pediatrics JO - Pediatrics VL - 123 IS - 4 N2 - OBJECTIVE: The aim of this study was to investigate the prevalence and possible association of inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. METHODS: We performed genotypic analysis for factor V G1691A, factor II G20210A, methylenetetrahydrofolate reductase C677T, and 4 common platelet glycoprotein polymorphisms (human platelet alloantigen-1, -2, -3, and -5) in 150 children <18 years of age with established diagnoses of stroke, transient ischemic attack, or migraine. Children were classified into 5 groups, namely, childhood arterial ischemic stroke (N = 33), perinatal arterial ischemic stroke (N = 26), hemorrhagic stroke (N = 20), transient ischemic attack (N = 36), and migraine (N = 35). The control group consisted of 112 children < or =18 years of age from the same geographical region who had no history of neurologic or thromboembolic diseases. RESULTS: Heterozygosity for factor V G1691A was associated with approximately sevenfold increased risk for arterial ischemic stroke, perinatal arterial ischemic stroke, and transient ischemic attack. Increased risk for transient ischemic attack was found in carriers of the human platelet alloantigen-2b allele, human platelet alloantigen-5a/b genotype, and combined human platelet alloantigen-2b and human platelet alloantigen-5b genotype. The presence of the human platelet alloantigen-2b allele was associated with a 2.23-fold increased risk for migraine, whereas carriers of the human platelet alloantigen-3b allele had a lower risk for arterial ischemic stroke than did carriers of the human platelet alloantigen-3a allele. CONCLUSIONS: Factor V G1691A has an important role in susceptibility to arterial ischemic stroke, both in the perinatal/neonatal period and in childhood, as well as transient ischemic attacks. A minor impact of human platelet alloantigen polymorphisms suggests that platelet glycoprotein polymorphisms may increase the risk of transient ischemic attacks and migraine, but this should be confirmed in larger studies. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/19336355/Inherited_prothrombotic_risk_factors_in_children_with_stroke_transient_ischemic_attack_or_migraine_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&amp;pmid=19336355 DB - PRIME DP - Unbound Medicine ER -