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Brain serotonin transporter binding in former users of MDMA ('ecstasy').
Br J Psychiatry. 2009 Apr; 194(4):355-9.BJ

Abstract

BACKGROUND

Animal experimental studies have prompted concerns that widespread use of 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') by young people may pose a major public health problem in terms of persistent serotonin neurotoxicity.

AIMS

To determine the status of brain serotonin neurons in a group of abstinent MDMA users.

METHOD

We assessed the integrity of brain serotonin neurons by measuring serotonin transporter (SERT) binding using positron emission tomography (PET) and [(11)C]DASB in 12 former MDMA users, 9 polydrug users who had never taken MDMA and 19 controls who reported no history of illicit drug use.

RESULTS

There was no significant difference in the binding potential of [(11)C]DASB between the groups in any of the brain regions examined.

CONCLUSIONS

To the extent that [(11)C]DASB binding provides an index of the integrity of serotonin neurons, our findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans.

Authors+Show Affiliations

PET Psychiatry, Cyclotron Building, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19336788

Citation

Selvaraj, Sudhakar, et al. "Brain Serotonin Transporter Binding in Former Users of MDMA ('ecstasy')." The British Journal of Psychiatry : the Journal of Mental Science, vol. 194, no. 4, 2009, pp. 355-9.
Selvaraj S, Hoshi R, Bhagwagar Z, et al. Brain serotonin transporter binding in former users of MDMA ('ecstasy'). Br J Psychiatry. 2009;194(4):355-9.
Selvaraj, S., Hoshi, R., Bhagwagar, Z., Murthy, N. V., Hinz, R., Cowen, P., Curran, H. V., & Grasby, P. (2009). Brain serotonin transporter binding in former users of MDMA ('ecstasy'). The British Journal of Psychiatry : the Journal of Mental Science, 194(4), 355-9. https://doi.org/10.1192/bjp.bp.108.050344
Selvaraj S, et al. Brain Serotonin Transporter Binding in Former Users of MDMA ('ecstasy'). Br J Psychiatry. 2009;194(4):355-9. PubMed PMID: 19336788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain serotonin transporter binding in former users of MDMA ('ecstasy'). AU - Selvaraj,Sudhakar, AU - Hoshi,Rosa, AU - Bhagwagar,Zubin, AU - Murthy,Naga Venkatesha, AU - Hinz,Rainer, AU - Cowen,Philip, AU - Curran,H Valerie, AU - Grasby,Paul, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/8/4/medline SP - 355 EP - 9 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 194 IS - 4 N2 - BACKGROUND: Animal experimental studies have prompted concerns that widespread use of 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') by young people may pose a major public health problem in terms of persistent serotonin neurotoxicity. AIMS: To determine the status of brain serotonin neurons in a group of abstinent MDMA users. METHOD: We assessed the integrity of brain serotonin neurons by measuring serotonin transporter (SERT) binding using positron emission tomography (PET) and [(11)C]DASB in 12 former MDMA users, 9 polydrug users who had never taken MDMA and 19 controls who reported no history of illicit drug use. RESULTS: There was no significant difference in the binding potential of [(11)C]DASB between the groups in any of the brain regions examined. CONCLUSIONS: To the extent that [(11)C]DASB binding provides an index of the integrity of serotonin neurons, our findings suggest that MDMA use may not result in long-term damage to serotonin neurons when used recreationally in humans. SN - 1472-1465 UR - https://www.unboundmedicine.com/medline/citation/19336788/Brain_serotonin_transporter_binding_in_former_users_of_MDMA__'ecstasy'__ L2 - https://www.cambridge.org/core/product/identifier/S0007125000249453/type/journal_article DB - PRIME DP - Unbound Medicine ER -