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Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis.
Br J Psychiatry 2009; 194(4):371-2BJ

Abstract

Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19336792

Citation

Koethe, Dagmar, et al. "Anandamide Elevation in Cerebrospinal Fluid in Initial Prodromal States of Psychosis." The British Journal of Psychiatry : the Journal of Mental Science, vol. 194, no. 4, 2009, pp. 371-2.
Koethe D, Giuffrida A, Schreiber D, et al. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. Br J Psychiatry. 2009;194(4):371-2.
Koethe, D., Giuffrida, A., Schreiber, D., Hellmich, M., Schultze-Lutter, F., Ruhrmann, S., ... Leweke, F. M. (2009). Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. The British Journal of Psychiatry : the Journal of Mental Science, 194(4), pp. 371-2. doi:10.1192/bjp.bp.108.053843.
Koethe D, et al. Anandamide Elevation in Cerebrospinal Fluid in Initial Prodromal States of Psychosis. Br J Psychiatry. 2009;194(4):371-2. PubMed PMID: 19336792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. AU - Koethe,Dagmar, AU - Giuffrida,Andrea, AU - Schreiber,Daniela, AU - Hellmich,Martin, AU - Schultze-Lutter,Frauke, AU - Ruhrmann,Stefan, AU - Klosterkötter,Joachim, AU - Piomelli,Daniele, AU - Leweke,F Markus, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/8/4/medline SP - 371 EP - 2 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 194 IS - 4 N2 - Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia. SN - 1472-1465 UR - https://www.unboundmedicine.com/medline/citation/19336792/Anandamide_elevation_in_cerebrospinal_fluid_in_initial_prodromal_states_of_psychosis_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000249490/type/journal_article DB - PRIME DP - Unbound Medicine ER -