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Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis.

Abstract

Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, J5, 68159 Mannheim, Germany.

    , , , , , , ,

    Source

    MeSH

    Adult
    Arachidonic Acids
    Cannabinoid Receptor Modulators
    Endocannabinoids
    Female
    Humans
    Male
    Mass Spectrometry
    Oleic Acids
    Polyunsaturated Alkamides
    Psychotic Disorders
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19336792

    Citation

    Koethe, Dagmar, et al. "Anandamide Elevation in Cerebrospinal Fluid in Initial Prodromal States of Psychosis." The British Journal of Psychiatry : the Journal of Mental Science, vol. 194, no. 4, 2009, pp. 371-2.
    Koethe D, Giuffrida A, Schreiber D, et al. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. Br J Psychiatry. 2009;194(4):371-2.
    Koethe, D., Giuffrida, A., Schreiber, D., Hellmich, M., Schultze-Lutter, F., Ruhrmann, S., ... Leweke, F. M. (2009). Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. The British Journal of Psychiatry : the Journal of Mental Science, 194(4), pp. 371-2. doi:10.1192/bjp.bp.108.053843.
    Koethe D, et al. Anandamide Elevation in Cerebrospinal Fluid in Initial Prodromal States of Psychosis. Br J Psychiatry. 2009;194(4):371-2. PubMed PMID: 19336792.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. AU - Koethe,Dagmar, AU - Giuffrida,Andrea, AU - Schreiber,Daniela, AU - Hellmich,Martin, AU - Schultze-Lutter,Frauke, AU - Ruhrmann,Stefan, AU - Klosterkötter,Joachim, AU - Piomelli,Daniele, AU - Leweke,F Markus, PY - 2009/4/2/entrez PY - 2009/4/2/pubmed PY - 2009/8/4/medline SP - 371 EP - 2 JF - The British journal of psychiatry : the journal of mental science JO - Br J Psychiatry VL - 194 IS - 4 N2 - Anandamide is a bioactive lipid binding to cannabinoid receptors. A homeostatic role for anandamide has been suggested in schizophrenia. We investigated its role in initial prodromal states of psychosis. We measured the levels of anandamide and its structural analog oleoylethanolamide in cerebrospinal fluid and serum of patients in the initial prodromal state (n=27) alongside healthy volunteers (n=81) using high-performance liquid chromatograph/mass spectrometry. Cerebrospinal anandamide levels in patients were significantly elevated. Patients with lower levels showed a higher risk for transiting to psychosis earlier. This anandamidergic up-regulation in the initial prodromal course may suggest a protective role of the endocannabinoid system in early schizophrenia. SN - 1472-1465 UR - https://www.unboundmedicine.com/medline/citation/19336792/Anandamide_elevation_in_cerebrospinal_fluid_in_initial_prodromal_states_of_psychosis_ L2 - https://www.cambridge.org/core/product/identifier/S0007125000249490/type/journal_article DB - PRIME DP - Unbound Medicine ER -