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Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system.
Pak J Pharm Sci. 2009 Apr; 22(2):175-9.PJ

Abstract

The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the concept of ion-activated in situ gelation. Sodium alginate was used as the gelling agent in combination with HPC (Hydroxy Propyl Cellulose) that acted as a viscosity-enhancing agent. In vitro release studies indicated that the alginate/HPC solution retained the drug better than the alginate or HPC solutions alone. The formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient compliance, industrially oriented and economical.

Authors+Show Affiliations

M.S Ramaiah College of Pharmacy, Bangalore-560054, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

19339228

Citation

Abraham, Sindhu, et al. "Sustained Ophthalmic Delivery of Ofloxacin From an Ion-activated in Situ Gelling System." Pakistan Journal of Pharmaceutical Sciences, vol. 22, no. 2, 2009, pp. 175-9.
Abraham S, Furtado S, Bharath S, et al. Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. Pak J Pharm Sci. 2009;22(2):175-9.
Abraham, S., Furtado, S., Bharath, S., Basavaraj, B. V., Deveswaran, R., & Madhavan, V. (2009). Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. Pakistan Journal of Pharmaceutical Sciences, 22(2), 175-9.
Abraham S, et al. Sustained Ophthalmic Delivery of Ofloxacin From an Ion-activated in Situ Gelling System. Pak J Pharm Sci. 2009;22(2):175-9. PubMed PMID: 19339228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained ophthalmic delivery of ofloxacin from an ion-activated in situ gelling system. AU - Abraham,Sindhu, AU - Furtado,Sharon, AU - Bharath,S, AU - Basavaraj,B V, AU - Deveswaran,R, AU - Madhavan,V, PY - 2009/4/3/entrez PY - 2009/4/3/pubmed PY - 2009/5/8/medline SP - 175 EP - 9 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 22 IS - 2 N2 - The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and then undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent ofloxacin, based on the concept of ion-activated in situ gelation. Sodium alginate was used as the gelling agent in combination with HPC (Hydroxy Propyl Cellulose) that acted as a viscosity-enhancing agent. In vitro release studies indicated that the alginate/HPC solution retained the drug better than the alginate or HPC solutions alone. The formulations were therapeutically efficacious, sterile, stable and provided sustained release of the drug over a period of time. These results demonstrate that the developed system is an alternative to conventional ophthalmic drops, patient compliance, industrially oriented and economical. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/19339228/Sustained_ophthalmic_delivery_of_ofloxacin_from_an_ion_activated_in_situ_gelling_system_ L2 - https://medlineplus.gov/eyecare.html DB - PRIME DP - Unbound Medicine ER -