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Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride.
Pak J Pharm Sci. 2009 Apr; 22(2):211-9.PJ

Abstract

In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily available. The granules of PPHCl were prepared by wet granulation method using a different ratios drug: gum ratios of X, LBG and XLBG(X and LBG in 1:1 ratios). To increase the flowability and compressibility of the granules, and to prevent its adhesion to punch and die, magnesium stearate and talc were added to the granules in 1:2 ratios before punching. The tablet was analysed to determine hardness, friability, % assay and invitro release study was carried out. The release of PPHCl from a gelatinous swollen mass, which controls the diffusion of drug molecules through the polymeric material into aqueous medium. The XLBG matrice shows precise controlled release than the X and LBG matrice because of burst effect and fast release in case of X and LBG matrice respectively and there was no chemical interaction between drug and polymer in XLBG formulation as confirmed by FTIR studies. First pass effect of PPHCl can be avoided by these formulations. Matrices with XLBG show zero-order release via swelling, diffusion and relaxation mechanism. The XLBG matrice leads to more precise result than X and LBG alone by the utilization of synergistic interaction between two biopolymers and uniformity in the hydration layer in dissolution media. However, according to the similarity factor (f(2)) XLBG3 were the most similar formulations to Lol-SR as the reference standard.

Authors+Show Affiliations

Department of Pharmaceutics, Parul Institute of Pharmacy, Limda, Baroda, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19339235

Citation

Rajesh, K S., et al. "Effect of Hydrophilic Natural Gums in Formulation of Oral-controlled Release Matrix Tablets of Propranolol Hydrochloride." Pakistan Journal of Pharmaceutical Sciences, vol. 22, no. 2, 2009, pp. 211-9.
Rajesh KS, Venkataraju MP, Gowda DV. Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride. Pak J Pharm Sci. 2009;22(2):211-9.
Rajesh, K. S., Venkataraju, M. P., & Gowda, D. V. (2009). Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride. Pakistan Journal of Pharmaceutical Sciences, 22(2), 211-9.
Rajesh KS, Venkataraju MP, Gowda DV. Effect of Hydrophilic Natural Gums in Formulation of Oral-controlled Release Matrix Tablets of Propranolol Hydrochloride. Pak J Pharm Sci. 2009;22(2):211-9. PubMed PMID: 19339235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride. AU - Rajesh,K S, AU - Venkataraju,M P, AU - Gowda,D V, PY - 2009/4/3/entrez PY - 2009/4/3/pubmed PY - 2009/5/8/medline SP - 211 EP - 9 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 22 IS - 2 N2 - In order to develop a controlled delivery of highly water-soluble propranolol hydrochloride (PPHCl) using hydrophilic natural gums (xanthan gum [X] and locust bean gum [LBG]) as cost-effective, nontoxic, easily available. The granules of PPHCl were prepared by wet granulation method using a different ratios drug: gum ratios of X, LBG and XLBG(X and LBG in 1:1 ratios). To increase the flowability and compressibility of the granules, and to prevent its adhesion to punch and die, magnesium stearate and talc were added to the granules in 1:2 ratios before punching. The tablet was analysed to determine hardness, friability, % assay and invitro release study was carried out. The release of PPHCl from a gelatinous swollen mass, which controls the diffusion of drug molecules through the polymeric material into aqueous medium. The XLBG matrice shows precise controlled release than the X and LBG matrice because of burst effect and fast release in case of X and LBG matrice respectively and there was no chemical interaction between drug and polymer in XLBG formulation as confirmed by FTIR studies. First pass effect of PPHCl can be avoided by these formulations. Matrices with XLBG show zero-order release via swelling, diffusion and relaxation mechanism. The XLBG matrice leads to more precise result than X and LBG alone by the utilization of synergistic interaction between two biopolymers and uniformity in the hydration layer in dissolution media. However, according to the similarity factor (f(2)) XLBG3 were the most similar formulations to Lol-SR as the reference standard. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/19339235/Effect_of_hydrophilic_natural_gums_in_formulation_of_oral_controlled_release_matrix_tablets_of_propranolol_hydrochloride_ L2 - https://antibodies.cancer.gov/detail/CPTC-SNCG-3 DB - PRIME DP - Unbound Medicine ER -