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Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods.
Am J Clin Nutr. 2009 May; 89(5):1602S-1606S.AJ

Abstract

Aging results in the development of cognitive and motor deficits in humans and animals that are evident by midlife. These deficits are thought to stem from neuronal damage and dysfunction as a result of a variety of stressors, including increased oxidative stress and modifications in brain lipid composition. Recent clinical and animal studies have identified nutritional intervention as a viable method to curtail the cognitive aging process. Human studies have been primarily observational and have indicated that inclusion of antioxidant-rich foods in the diet can slow the progression of cognitive decline. Basic science studies investigating nutritional modulation of age-related cognitive decline have focused on foods rich in antioxidants or essential fatty acids. The purpose of this review is to discuss recent advancements in animal research showing that age-related cognitive and behavioral decline can be ameliorated with nutritional supplementation with polyphenol- or polyunsaturated fatty acid-rich plant foods.

Authors+Show Affiliations

US Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

19339395

Citation

Willis, Lauren M., et al. "Modulation of Cognition and Behavior in Aged Animals: Role for Antioxidant- and Essential Fatty Acid-rich Plant Foods." The American Journal of Clinical Nutrition, vol. 89, no. 5, 2009, 1602S-1606S.
Willis LM, Shukitt-Hale B, Joseph JA. Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods. Am J Clin Nutr. 2009;89(5):1602S-1606S.
Willis, L. M., Shukitt-Hale, B., & Joseph, J. A. (2009). Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods. The American Journal of Clinical Nutrition, 89(5), 1602S-1606S. https://doi.org/10.3945/ajcn.2009.26736J
Willis LM, Shukitt-Hale B, Joseph JA. Modulation of Cognition and Behavior in Aged Animals: Role for Antioxidant- and Essential Fatty Acid-rich Plant Foods. Am J Clin Nutr. 2009;89(5):1602S-1606S. PubMed PMID: 19339395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of cognition and behavior in aged animals: role for antioxidant- and essential fatty acid-rich plant foods. AU - Willis,Lauren M, AU - Shukitt-Hale,Barbara, AU - Joseph,James A, Y1 - 2009/04/01/ PY - 2009/4/3/entrez PY - 2009/4/3/pubmed PY - 2009/5/15/medline SP - 1602S EP - 1606S JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 89 IS - 5 N2 - Aging results in the development of cognitive and motor deficits in humans and animals that are evident by midlife. These deficits are thought to stem from neuronal damage and dysfunction as a result of a variety of stressors, including increased oxidative stress and modifications in brain lipid composition. Recent clinical and animal studies have identified nutritional intervention as a viable method to curtail the cognitive aging process. Human studies have been primarily observational and have indicated that inclusion of antioxidant-rich foods in the diet can slow the progression of cognitive decline. Basic science studies investigating nutritional modulation of age-related cognitive decline have focused on foods rich in antioxidants or essential fatty acids. The purpose of this review is to discuss recent advancements in animal research showing that age-related cognitive and behavioral decline can be ameliorated with nutritional supplementation with polyphenol- or polyunsaturated fatty acid-rich plant foods. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19339395/Modulation_of_cognition_and_behavior_in_aged_animals:_role_for_antioxidant__and_essential_fatty_acid_rich_plant_foods_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.26736J DB - PRIME DP - Unbound Medicine ER -