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How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins.
J Cell Sci. 2009 Apr 15; 122(Pt 8):1071-9.JC

Abstract

The ingression of a cleavage furrow separates the two daughter cells at the end of cell division. In many organisms this furrow ingression is driven by the assembly and contraction of actomyosin filaments, forming a contractile ring. To achieve a successful cytokinesis, these actomyosin filaments need to be assembled in an organized manner. For this purpose, a network of cytoskeletal proteins is built at the cleavage site to act as a scaffold for actomyosin filaments and to connect them to the plasma membrane. The Drosophila melanogaster protein Anillin, and its related proteins in other organisms, has a pivotal role in the organization of this scaffold in many species, ranging from yeast to humans. Recent studies indicate that Anillin-related proteins interact not only with the structural components of the contractile ring, but also with the signalling factors that control their dynamics. In addition, Drosophila Anillin connects the actomyosin ring to the spindle microtubules through its interaction with the RacGAP component of the centralspindlin complex. Here I review the structures and functions of Anillin and Anillin-related proteins in various model systems, and aim to highlight both the common and distinctive features of these essential organizers of the molecular machinery that drives furrow ingression.

Authors+Show Affiliations

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK. ppd21@hermes.cam.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19339546

Citation

D'Avino, Pier Paolo. "How to Scaffold the Contractile Ring for a Safe Cytokinesis - Lessons From Anillin-related Proteins." Journal of Cell Science, vol. 122, no. Pt 8, 2009, pp. 1071-9.
D'Avino PP. How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins. J Cell Sci. 2009;122(Pt 8):1071-9.
D'Avino, P. P. (2009). How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins. Journal of Cell Science, 122(Pt 8), 1071-9. https://doi.org/10.1242/jcs.034785
D'Avino PP. How to Scaffold the Contractile Ring for a Safe Cytokinesis - Lessons From Anillin-related Proteins. J Cell Sci. 2009 Apr 15;122(Pt 8):1071-9. PubMed PMID: 19339546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How to scaffold the contractile ring for a safe cytokinesis - lessons from Anillin-related proteins. A1 - D'Avino,Pier Paolo, PY - 2009/4/3/entrez PY - 2009/4/3/pubmed PY - 2009/6/12/medline SP - 1071 EP - 9 JF - Journal of cell science JO - J Cell Sci VL - 122 IS - Pt 8 N2 - The ingression of a cleavage furrow separates the two daughter cells at the end of cell division. In many organisms this furrow ingression is driven by the assembly and contraction of actomyosin filaments, forming a contractile ring. To achieve a successful cytokinesis, these actomyosin filaments need to be assembled in an organized manner. For this purpose, a network of cytoskeletal proteins is built at the cleavage site to act as a scaffold for actomyosin filaments and to connect them to the plasma membrane. The Drosophila melanogaster protein Anillin, and its related proteins in other organisms, has a pivotal role in the organization of this scaffold in many species, ranging from yeast to humans. Recent studies indicate that Anillin-related proteins interact not only with the structural components of the contractile ring, but also with the signalling factors that control their dynamics. In addition, Drosophila Anillin connects the actomyosin ring to the spindle microtubules through its interaction with the RacGAP component of the centralspindlin complex. Here I review the structures and functions of Anillin and Anillin-related proteins in various model systems, and aim to highlight both the common and distinctive features of these essential organizers of the molecular machinery that drives furrow ingression. SN - 0021-9533 UR - https://www.unboundmedicine.com/medline/citation/19339546/How_to_scaffold_the_contractile_ring_for_a_safe_cytokinesis___lessons_from_Anillin_related_proteins_ L2 - http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=19339546 DB - PRIME DP - Unbound Medicine ER -