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Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome.
Eur J Contracept Reprod Health Care. 2009 Apr; 14(2):153-9.EJ

Abstract

OBJECTIVES

To compare serum leptin levels in women with polycystic ovary syndrome (PCOS) and healthy subjects, and to evaluate the relationship between leptin concentration and insulin resistance.

METHODS

Forty-five women with PCOS and 20 controls were included in the study. Serum levels of leptin, testosterone, immune-reactive insulin (IRI), sex hormone-binding globulin, dehydroepiandrosterone sulfate, cortisol, LH and FSH were measured. Free androgen index (FAI) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Body mass index (BMI) and waist-to-hip ratio (WHR) were assessed.

RESULTS

Serum leptin levels in PCOS patients were higher than in the control group independently of BMI, WHR and waist circumference. In PCOS patients there was a strong positive correlation between leptin and IRI (r = 0.592, p < 0.01) on the one hand, and leptin and HOMA-IR, on the other (r = 0.637, p < 0.01). In PCOS patients with more pronounced insulin resistance (IR) the correlation between leptin levels and HOMA-IR is independent of BMI, WHR and waist circumference. We did not find any correlation between leptin and other hormonal indices in PCOS patients.

CONCLUSIONS

Our study confirms the existence of a significant positive correlation between serum leptin levels and clinical and hormonal indices of IR. The hyperleptinaemia is probably due to leptin resistance and may be characteristic of the syndrome. The lack of correlation with other hormonal parameters is probably due to the heterogeneity of the PCOS group.

Links

Publisher Full Text

Authors+Show Affiliations

Pehlivanov B
Department of Obstetrics and Gynaecology, Medical University, Plovdiv, Bulgaria. blago1956@yahoo.com
Mitkov M
No affiliation info available

MeSH

AdolescentAdultBody Mass IndexCase-Control StudiesFemaleFollicle Stimulating HormoneHumansInsulinInsulin ResistanceLeptinLogistic ModelsObesityPolycystic Ovary SyndromeStatistics, NonparametricTestosteroneWaist CircumferenceWaist-Hip RatioYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19340711

Citation

Pehlivanov, Blagovest, and Mitko Mitkov. "Serum Leptin Levels Correlate With Clinical and Biochemical Indices of Insulin Resistance in Women With Polycystic Ovary Syndrome." The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, vol. 14, no. 2, 2009, pp. 153-9.
Pehlivanov B, Mitkov M. Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome. Eur J Contracept Reprod Health Care. 2009;14(2):153-9.
Pehlivanov, B., & Mitkov, M. (2009). Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome. The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception, 14(2), 153-9. https://doi.org/10.1080/13625180802549962
Pehlivanov B, Mitkov M. Serum Leptin Levels Correlate With Clinical and Biochemical Indices of Insulin Resistance in Women With Polycystic Ovary Syndrome. Eur J Contracept Reprod Health Care. 2009;14(2):153-9. PubMed PMID: 19340711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin levels correlate with clinical and biochemical indices of insulin resistance in women with polycystic ovary syndrome. AU - Pehlivanov,Blagovest, AU - Mitkov,Mitko, PY - 2009/4/3/entrez PY - 2009/4/3/pubmed PY - 2009/6/3/medline SP - 153 EP - 9 JF - The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception JO - Eur J Contracept Reprod Health Care VL - 14 IS - 2 N2 - OBJECTIVES: To compare serum leptin levels in women with polycystic ovary syndrome (PCOS) and healthy subjects, and to evaluate the relationship between leptin concentration and insulin resistance. METHODS: Forty-five women with PCOS and 20 controls were included in the study. Serum levels of leptin, testosterone, immune-reactive insulin (IRI), sex hormone-binding globulin, dehydroepiandrosterone sulfate, cortisol, LH and FSH were measured. Free androgen index (FAI) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. Body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. RESULTS: Serum leptin levels in PCOS patients were higher than in the control group independently of BMI, WHR and waist circumference. In PCOS patients there was a strong positive correlation between leptin and IRI (r = 0.592, p < 0.01) on the one hand, and leptin and HOMA-IR, on the other (r = 0.637, p < 0.01). In PCOS patients with more pronounced insulin resistance (IR) the correlation between leptin levels and HOMA-IR is independent of BMI, WHR and waist circumference. We did not find any correlation between leptin and other hormonal indices in PCOS patients. CONCLUSIONS: Our study confirms the existence of a significant positive correlation between serum leptin levels and clinical and hormonal indices of IR. The hyperleptinaemia is probably due to leptin resistance and may be characteristic of the syndrome. The lack of correlation with other hormonal parameters is probably due to the heterogeneity of the PCOS group. SN - 1473-0782 UR - https://www.unboundmedicine.com/medline/citation/19340711/Serum_leptin_levels_correlate_with_clinical_and_biochemical_indices_of_insulin_resistance_in_women_with_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.1080/13625180802549962 DB - PRIME DP - Unbound Medicine ER -