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Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam.
Virology. 2009 May 10; 387(2):250-6.V

Abstract

Highly pathogenic avian influenza H5N1 virus was detected in poultry seized at two ports of entry located in Lang Son Province, Vietnam. Sequence analysis of the hemagglutinin (HA) genes from five H5N1 virus isolates and ten PCR amplicons from chicken cloacal samples revealed their close phylogenetic relationship to clade 7 H5N1 HA genes. However, these HA genes exhibited extensive genetic divergence at both the nucleotide and amino acid levels in comparison to previously described clade 7 viruses; e.g., A/chicken/Shanxi/2/2006. In addition, hemagglutination inhibition tests revealed antigenic differences between these and previously isolated H5N1 viruses from Vietnam. These results indicate that viruses with clade 7 HA are evolving rapidly in poultry in Southeast Asia.

Authors+Show Affiliations

National Centre for Veterinary Diagnostics, Department of Animal Health, Hanoi, Vietnam.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19342072

Citation

Nguyen, Tung, et al. "Characterization of a Highly Pathogenic Avian Influenza H5N1 Virus Sublineage in Poultry Seized at Ports of Entry Into Vietnam." Virology, vol. 387, no. 2, 2009, pp. 250-6.
Nguyen T, Davis CT, Stembridge W, et al. Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam. Virology. 2009;387(2):250-6.
Nguyen, T., Davis, C. T., Stembridge, W., Shu, B., Balish, A., Inui, K., Do, H. T., Ngo, H. T., Wan, X. F., McCarron, M., Lindstrom, S. E., Cox, N. J., Nguyen, C. V., Klimov, A. I., & Donis, R. O. (2009). Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam. Virology, 387(2), 250-6. https://doi.org/10.1016/j.virol.2009.03.006
Nguyen T, et al. Characterization of a Highly Pathogenic Avian Influenza H5N1 Virus Sublineage in Poultry Seized at Ports of Entry Into Vietnam. Virology. 2009 May 10;387(2):250-6. PubMed PMID: 19342072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam. AU - Nguyen,Tung, AU - Davis,C Todd, AU - Stembridge,William, AU - Shu,Bo, AU - Balish,Amanda, AU - Inui,Kenjiro, AU - Do,Hoa T, AU - Ngo,Huong T, AU - Wan,Xiu-Feng, AU - McCarron,Margaret, AU - Lindstrom,Stephen E, AU - Cox,Nancy J, AU - Nguyen,Cam V, AU - Klimov,Alexander I, AU - Donis,Ruben O, Y1 - 2009/04/02/ PY - 2009/01/10/received PY - 2009/02/12/revised PY - 2009/03/06/accepted PY - 2009/4/4/entrez PY - 2009/4/4/pubmed PY - 2009/6/6/medline SP - 250 EP - 6 JF - Virology JO - Virology VL - 387 IS - 2 N2 - Highly pathogenic avian influenza H5N1 virus was detected in poultry seized at two ports of entry located in Lang Son Province, Vietnam. Sequence analysis of the hemagglutinin (HA) genes from five H5N1 virus isolates and ten PCR amplicons from chicken cloacal samples revealed their close phylogenetic relationship to clade 7 H5N1 HA genes. However, these HA genes exhibited extensive genetic divergence at both the nucleotide and amino acid levels in comparison to previously described clade 7 viruses; e.g., A/chicken/Shanxi/2/2006. In addition, hemagglutination inhibition tests revealed antigenic differences between these and previously isolated H5N1 viruses from Vietnam. These results indicate that viruses with clade 7 HA are evolving rapidly in poultry in Southeast Asia. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/19342072/Characterization_of_a_highly_pathogenic_avian_influenza_H5N1_virus_sublineage_in_poultry_seized_at_ports_of_entry_into_Vietnam_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(09)00181-0 DB - PRIME DP - Unbound Medicine ER -