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Marker of death from hemorrhagic shock.
Leg Med (Tokyo). 2009 Apr; 11 Suppl 1:S241-3.LM

Abstract

Hemorrhagic shock has often been cited as a cause of death in forensic practical cases, but it is usually difficult to prove by autopsy findings alone. Our experimental studies demonstrated that hemorrhagic shock has promoted the endovascular recruitment of activated neutrophils and finally led to dysfunction of the shock organs. In this study, activated neutrophils were studied as a marker of death from hemorrhagic shock in the organs of autopsy cases in our department. Morphological changes in the heart, lung, liver, and kidney were examined in cases of death from hemorrhagic shock. The frequency of appearance of activated neutrophils was measured by immunohistochemical staining in the organs. The commonly observed morphological changes of hemorrhagic shock, which were not always expressed in any cases, could not account well for the cause of death. However, the expression of activated neutrophils in the organs elevated significantly at a middle and long antemortem interval. The appearance of activated neutrophils in the shock organs might be useful as a morphological marker of the cause of death from hemorrhagic shock in forensic practice cases.

Authors+Show Affiliations

Department of Forensic Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. h-sato@med.uoeh-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19342270

Citation

Sato, Hiroaki, et al. "Marker of Death From Hemorrhagic Shock." Legal Medicine (Tokyo, Japan), vol. 11 Suppl 1, 2009, pp. S241-3.
Sato H, Kita T, Tanaka T, et al. Marker of death from hemorrhagic shock. Leg Med (Tokyo). 2009;11 Suppl 1:S241-3.
Sato, H., Kita, T., Tanaka, T., Kasai, K., & Tanaka, N. (2009). Marker of death from hemorrhagic shock. Legal Medicine (Tokyo, Japan), 11 Suppl 1, S241-3. https://doi.org/10.1016/j.legalmed.2009.02.048
Sato H, et al. Marker of Death From Hemorrhagic Shock. Leg Med (Tokyo). 2009;11 Suppl 1:S241-3. PubMed PMID: 19342270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marker of death from hemorrhagic shock. AU - Sato,Hiroaki, AU - Kita,Toshiro, AU - Tanaka,Toshiko, AU - Kasai,Kentaro, AU - Tanaka,Noriyuki, Y1 - 2009/04/01/ PY - 2008/12/08/received PY - 2009/01/13/revised PY - 2009/02/09/accepted PY - 2009/4/4/entrez PY - 2009/4/4/pubmed PY - 2010/1/27/medline SP - S241 EP - 3 JF - Legal medicine (Tokyo, Japan) JO - Leg Med (Tokyo) VL - 11 Suppl 1 N2 - Hemorrhagic shock has often been cited as a cause of death in forensic practical cases, but it is usually difficult to prove by autopsy findings alone. Our experimental studies demonstrated that hemorrhagic shock has promoted the endovascular recruitment of activated neutrophils and finally led to dysfunction of the shock organs. In this study, activated neutrophils were studied as a marker of death from hemorrhagic shock in the organs of autopsy cases in our department. Morphological changes in the heart, lung, liver, and kidney were examined in cases of death from hemorrhagic shock. The frequency of appearance of activated neutrophils was measured by immunohistochemical staining in the organs. The commonly observed morphological changes of hemorrhagic shock, which were not always expressed in any cases, could not account well for the cause of death. However, the expression of activated neutrophils in the organs elevated significantly at a middle and long antemortem interval. The appearance of activated neutrophils in the shock organs might be useful as a morphological marker of the cause of death from hemorrhagic shock in forensic practice cases. SN - 1873-4162 UR - https://www.unboundmedicine.com/medline/citation/19342270/Marker_of_death_from_hemorrhagic_shock_ DB - PRIME DP - Unbound Medicine ER -