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Nutrient supplementation approaches in the treatment of ADHD.
Expert Rev Neurother 2009; 9(4):461-76ER

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a chronic, debilitating psychiatric illness that often co-occurs with other common psychiatric problems. Although empirical evidence supports pharmacological and behavioral treatments, side effects, concerns regarding safety and fears about long-term use all contribute to families searching for alternative methods of treating the symptoms of ADHD. This review presents the published evidence on supplementation, including single ingredients (e.g., minerals, vitamins, amino acids and essential fatty acids), botanicals and multi-ingredient formulas in the treatment of ADHD symptoms. In most cases, evidence is sparse, mixed and lacking information. Of those supplements where we found published studies, the evidence is best for zinc (two positive randomized, controlled trials); there is mixed evidence for carnitine, pycnogenol and essential fatty acids, and more research is needed before drawing conclusions about vitamins, magnesium, iron, SAM-e, tryptophan and Ginkgo biloba with ginseng. To date, there is no evidence to support the use of St John's wort, tyrosine or phenylalanine in the treatment of ADHD symptoms. Multi-ingredient approaches are an intriguing yet under-researched area; we discuss the benefits of this approach considering the heterogeneous nature of ADHD.

Authors+Show Affiliations

Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand. julia.rucklidge@canterbury.ac.nzNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19344299

Citation

Rucklidge, Julia J., et al. "Nutrient Supplementation Approaches in the Treatment of ADHD." Expert Review of Neurotherapeutics, vol. 9, no. 4, 2009, pp. 461-76.
Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient supplementation approaches in the treatment of ADHD. Expert Rev Neurother. 2009;9(4):461-76.
Rucklidge, J. J., Johnstone, J., & Kaplan, B. J. (2009). Nutrient supplementation approaches in the treatment of ADHD. Expert Review of Neurotherapeutics, 9(4), pp. 461-76. doi:10.1586/ern.09.7.
Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient Supplementation Approaches in the Treatment of ADHD. Expert Rev Neurother. 2009;9(4):461-76. PubMed PMID: 19344299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutrient supplementation approaches in the treatment of ADHD. AU - Rucklidge,Julia J, AU - Johnstone,Jeanette, AU - Kaplan,Bonnie J, PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2009/6/26/medline SP - 461 EP - 76 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 9 IS - 4 N2 - Attention-deficit/hyperactivity disorder (ADHD) is a chronic, debilitating psychiatric illness that often co-occurs with other common psychiatric problems. Although empirical evidence supports pharmacological and behavioral treatments, side effects, concerns regarding safety and fears about long-term use all contribute to families searching for alternative methods of treating the symptoms of ADHD. This review presents the published evidence on supplementation, including single ingredients (e.g., minerals, vitamins, amino acids and essential fatty acids), botanicals and multi-ingredient formulas in the treatment of ADHD symptoms. In most cases, evidence is sparse, mixed and lacking information. Of those supplements where we found published studies, the evidence is best for zinc (two positive randomized, controlled trials); there is mixed evidence for carnitine, pycnogenol and essential fatty acids, and more research is needed before drawing conclusions about vitamins, magnesium, iron, SAM-e, tryptophan and Ginkgo biloba with ginseng. To date, there is no evidence to support the use of St John's wort, tyrosine or phenylalanine in the treatment of ADHD symptoms. Multi-ingredient approaches are an intriguing yet under-researched area; we discuss the benefits of this approach considering the heterogeneous nature of ADHD. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/19344299/Nutrient_supplementation_approaches_in_the_treatment_of_ADHD_ L2 - http://www.tandfonline.com/doi/full/10.1586/ern.09.7 DB - PRIME DP - Unbound Medicine ER -