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Curcumin prevents oxidative renal damage induced by acetaminophen in rats.
Food Chem Toxicol. 2009 Jul; 47(7):1480-4.FC

Abstract

Acetaminophen (APAP) can cause life-threatening renal damages and there is no specific treatment for APAP-induced renal damage. The aim of this study was to investigate the protective effects of curcumin (CMN) on APAP-induced nephrotoxicity. Nephrotoxicity was induced in male Wistar Albino rats by the administration of a single dose of 1000 mg/kg APAP intraperitoneally (i.p.). Some of these rats also received i.p. CMN (200mg/kg) at 30 min after the administration of APAP. Twenty-four hours after the administration of APAP, all the rats were sacrificed with a high dose of ketamine. Urea and creatinine levels were measured in the blood, and the levels of malondialdehyde (MDA) and glutathione (GSH), and antioxidant enzyme activity were determined in the renal tissue. Histopathological changes were studied. APAP administration caused elevated levels of renal MDA, and marked depletion of GSH levels and antioxidant enzyme activity, and deteriorated the renal functions as assessed by the increased plasma urea and creatinine levels as compared to control rats. CMN markedly reduced the elevated MDA levels, significantly increased the antioxidant enzyme activity and normalized the altered renal morphology in rats treated with APAP. CMN might be a potential candidate agent against APAP-induced nephrotoxicity, but further studies are required to identify this issue before clinical application becomes possible.

Authors+Show Affiliations

Department of Biochemistry, Kocaeli University, Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19345714

Citation

Cekmen, M, et al. "Curcumin Prevents Oxidative Renal Damage Induced By Acetaminophen in Rats." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 47, no. 7, 2009, pp. 1480-4.
Cekmen M, Ilbey YO, Ozbek E, et al. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem Toxicol. 2009;47(7):1480-4.
Cekmen, M., Ilbey, Y. O., Ozbek, E., Simsek, A., Somay, A., & Ersoz, C. (2009). Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 47(7), 1480-4. https://doi.org/10.1016/j.fct.2009.03.034
Cekmen M, et al. Curcumin Prevents Oxidative Renal Damage Induced By Acetaminophen in Rats. Food Chem Toxicol. 2009;47(7):1480-4. PubMed PMID: 19345714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curcumin prevents oxidative renal damage induced by acetaminophen in rats. AU - Cekmen,M, AU - Ilbey,Y O, AU - Ozbek,E, AU - Simsek,A, AU - Somay,A, AU - Ersoz,C, Y1 - 2009/04/02/ PY - 2009/01/10/received PY - 2009/03/24/revised PY - 2009/03/26/accepted PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2009/8/29/medline SP - 1480 EP - 4 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 47 IS - 7 N2 - Acetaminophen (APAP) can cause life-threatening renal damages and there is no specific treatment for APAP-induced renal damage. The aim of this study was to investigate the protective effects of curcumin (CMN) on APAP-induced nephrotoxicity. Nephrotoxicity was induced in male Wistar Albino rats by the administration of a single dose of 1000 mg/kg APAP intraperitoneally (i.p.). Some of these rats also received i.p. CMN (200mg/kg) at 30 min after the administration of APAP. Twenty-four hours after the administration of APAP, all the rats were sacrificed with a high dose of ketamine. Urea and creatinine levels were measured in the blood, and the levels of malondialdehyde (MDA) and glutathione (GSH), and antioxidant enzyme activity were determined in the renal tissue. Histopathological changes were studied. APAP administration caused elevated levels of renal MDA, and marked depletion of GSH levels and antioxidant enzyme activity, and deteriorated the renal functions as assessed by the increased plasma urea and creatinine levels as compared to control rats. CMN markedly reduced the elevated MDA levels, significantly increased the antioxidant enzyme activity and normalized the altered renal morphology in rats treated with APAP. CMN might be a potential candidate agent against APAP-induced nephrotoxicity, but further studies are required to identify this issue before clinical application becomes possible. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/19345714/Curcumin_prevents_oxidative_renal_damage_induced_by_acetaminophen_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(09)00142-2 DB - PRIME DP - Unbound Medicine ER -