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Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene.
Int Immunopharmacol. 2009 Jul; 9(7-8):918-24.II

Abstract

Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma.

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Authors+Show Affiliations

Choi JR
Department of Microbiology and Immunology, Pusan National University School of Medicine, Busan 602-739, South Korea.
Lee CM
No affiliation info available
Jung ID
No affiliation info available
Lee JS
No affiliation info available
Jeong YI
No affiliation info available
Chang JH
No affiliation info available
Park HJ
No affiliation info available
Choi IW
No affiliation info available
Kim JS
No affiliation info available
Shin YK
No affiliation info available
Park SN
No affiliation info available
Park YM
No affiliation info available

MeSH

Airway ObstructionAnimalsApigeninAsthmaBronchoalveolar Lavage FluidCell MovementCytokinesEnzyme-Linked Immunosorbent AssayEosinophil PeroxidaseEosinophiliaEosinophilsFemaleGATA3 Transcription FactorImmunizationImmunoglobulin ELungMatrix Metalloproteinase 9MiceMice, Inbred BALB COvalbumin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19345747

Citation

Choi, Jun-Rim, et al. "Apigenin Protects Ovalbumin-induced Asthma Through the Regulation of GATA-3 Gene." International Immunopharmacology, vol. 9, no. 7-8, 2009, pp. 918-24.
Choi JR, Lee CM, Jung ID, et al. Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. Int Immunopharmacol. 2009;9(7-8):918-24.
Choi, J. R., Lee, C. M., Jung, I. D., Lee, J. S., Jeong, Y. I., Chang, J. H., Park, H. J., Choi, I. W., Kim, J. S., Shin, Y. K., Park, S. N., & Park, Y. M. (2009). Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. International Immunopharmacology, 9(7-8), 918-24. https://doi.org/10.1016/j.intimp.2009.03.018
Choi JR, et al. Apigenin Protects Ovalbumin-induced Asthma Through the Regulation of GATA-3 Gene. Int Immunopharmacol. 2009;9(7-8):918-24. PubMed PMID: 19345747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene. AU - Choi,Jun-Rim, AU - Lee,Chang-Min, AU - Jung,In Duk, AU - Lee,Jun Sik, AU - Jeong,Young-Il, AU - Chang,Jeong Hyun, AU - Park,Hee-Ju, AU - Choi,Il-Whan, AU - Kim,Jong-Suk, AU - Shin,Yong Kyoo, AU - Park,Sung Nam, AU - Park,Yeong-Min, Y1 - 2009/04/05/ PY - 2009/02/16/received PY - 2009/03/23/revised PY - 2009/03/26/accepted PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2009/11/17/medline SP - 918 EP - 24 JF - International immunopharmacology JO - Int Immunopharmacol VL - 9 IS - 7-8 N2 - Apigenin, a dietary plant-flavonoid has shown anti-inflammatory and anticancer properties, however the molecular basis of this effect remains to be elucidated. Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions. It included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of apigenin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that apigenin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of apigenin in terms of its effects in a murine model of asthma. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/19345747/Apigenin_protects_ovalbumin_induced_asthma_through_the_regulation_of_GATA_3_gene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(09)00125-8 DB - PRIME DP - Unbound Medicine ER -