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Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex.

Abstract

Here we have examined the connection between IgA deficiency, IgG subclass deficiency, and the absence of alleles of complement C4, and show that IgA deficient subjects who have IgG subclass deficiencies may also have an increased frequency of C4 null alleles. In our group, we found an increased incidence of HLA B38 which might reflect the ethnic composition of the patients tested. While family studies are of primary importance to assess the relationships between histocompatibility antigens and immune deficiency, these studies are complicated by the observation that C4 null alleles are not always inherited with the humoral defect.

Authors+Show Affiliations

,

Department of Medicine, Mount Sinai Medical Center, New York City, New York 10029.

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Source

Clinical immunology and immunopathology 61:2 Pt 2 1991 Nov pg S61-9

MeSH

Adult
Child
Chromosomes, Human, Pair 6
Complement C4a
Dysgammaglobulinemia
Female
HLA Antigens
HLA-A1 Antigen
HLA-B8 Antigen
HLA-DR3 Antigen
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunophenotyping
Infant
Male
Middle Aged
Pedigree

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1934614

Citation

Cunningham-Rundles, C, et al. "Selective IgA Deficiency, IgG Subclass Deficiency, and the Major Histocompatibility Complex." Clinical Immunology and Immunopathology, vol. 61, no. 2 Pt 2, 1991, pp. S61-9.
Cunningham-Rundles C, Fotino M, Rosina O, et al. Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex. Clin Immunol Immunopathol. 1991;61(2 Pt 2):S61-9.
Cunningham-Rundles, C., Fotino, M., Rosina, O., & Peter, J. B. (1991). Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex. Clinical Immunology and Immunopathology, 61(2 Pt 2), pp. S61-9.
Cunningham-Rundles C, et al. Selective IgA Deficiency, IgG Subclass Deficiency, and the Major Histocompatibility Complex. Clin Immunol Immunopathol. 1991;61(2 Pt 2):S61-9. PubMed PMID: 1934614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective IgA deficiency, IgG subclass deficiency, and the major histocompatibility complex. AU - Cunningham-Rundles,C, AU - Fotino,M, AU - Rosina,O, AU - Peter,J B, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - S61 EP - 9 JF - Clinical immunology and immunopathology JO - Clin. Immunol. Immunopathol. VL - 61 IS - 2 Pt 2 N2 - Here we have examined the connection between IgA deficiency, IgG subclass deficiency, and the absence of alleles of complement C4, and show that IgA deficient subjects who have IgG subclass deficiencies may also have an increased frequency of C4 null alleles. In our group, we found an increased incidence of HLA B38 which might reflect the ethnic composition of the patients tested. While family studies are of primary importance to assess the relationships between histocompatibility antigens and immune deficiency, these studies are complicated by the observation that C4 null alleles are not always inherited with the humoral defect. SN - 0090-1229 UR - https://www.unboundmedicine.com/medline/citation/1934614/Selective_IgA_deficiency_IgG_subclass_deficiency_and_the_major_histocompatibility_complex_ L2 - http://www.diseaseinfosearch.org/result/6492 DB - PRIME DP - Unbound Medicine ER -