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The current prevalence and factors associated with tardive dyskinesia among Filipino schizophrenic patients.
Parkinsonism Relat Disord. 2009 Nov; 15(9):655-9.PR

Abstract

OBJECTIVE

To determine the prevalence of and the factors associated with tardive dyskinesia (TD) among Filipino patients with schizophrenia admitted at the National Center for Mental Health.

STUDY DESIGN

Cross-sectional study.

METHODS

A total of 227 inpatients fulfilling the DSM-IV TR criteria for schizophrenia participated in the study. Demographic data including age, disease duration and medication intake were obtained. The Abnormal Involuntary Movement Scale (AIMS) and Simpson Angus Rating Scale (SARS) were performed on all patients. Odds of developing TD in relation to the different variables were computed. The association between study variables and development of TD was also evaluated using the Chi-square test.

FINDINGS

Our cohort of patients had a mean age of 40 (range: 19-73 years old), had a mean disease duration of 6 years, had a daily neuroleptic dose of 700 mg in chlorpromazine equivalent, and had a lifetime neuroleptic exposure of at least 5 years. The prevalence rate of TD was 20.3% (46 out of 227 patients). Fifty-three percent of patients had significant extrapyramidal features (SARS > or =3). TD was noted more in females and older age groups. The other factors associated with TD: were those patients with longer duration of illness and those patients with longer cumulative exposure to neuroleptic drugs. There was no association found with regard to the presence of diabetes mellitus type II, to the use of anticholinergic drugs, to the history of substance abuse and to the history of electroconvulsive therapy.

CONCLUSIONS

Despite the predominant use of first-generation antipsychotic agents, the prevalence of TD among Filipino schizophrenic patients is similar to that reported among Asians, but lower than that reported among our Western counterparts. The results may be affected by differences in methodological, racial and genetic determinants.

Authors+Show Affiliations

Department of Neurology and Psychiatry, University of Santo Tomas Hospital, Manila, Philippines.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19346155

Citation

Go, Criscely L., et al. "The Current Prevalence and Factors Associated With Tardive Dyskinesia Among Filipino Schizophrenic Patients." Parkinsonism & Related Disorders, vol. 15, no. 9, 2009, pp. 655-9.
Go CL, Rosales RL, Caraos RJ, et al. The current prevalence and factors associated with tardive dyskinesia among Filipino schizophrenic patients. Parkinsonism Relat Disord. 2009;15(9):655-9.
Go, C. L., Rosales, R. L., Caraos, R. J., & Fernandez, H. H. (2009). The current prevalence and factors associated with tardive dyskinesia among Filipino schizophrenic patients. Parkinsonism & Related Disorders, 15(9), 655-9. https://doi.org/10.1016/j.parkreldis.2009.02.015
Go CL, et al. The Current Prevalence and Factors Associated With Tardive Dyskinesia Among Filipino Schizophrenic Patients. Parkinsonism Relat Disord. 2009;15(9):655-9. PubMed PMID: 19346155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The current prevalence and factors associated with tardive dyskinesia among Filipino schizophrenic patients. AU - Go,Criscely L, AU - Rosales,Raymond L, AU - Caraos,Rico J, AU - Fernandez,Hubert H, Y1 - 2009/04/05/ PY - 2008/09/30/received PY - 2009/02/25/revised PY - 2009/02/26/accepted PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2010/1/9/medline SP - 655 EP - 9 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 IS - 9 N2 - OBJECTIVE: To determine the prevalence of and the factors associated with tardive dyskinesia (TD) among Filipino patients with schizophrenia admitted at the National Center for Mental Health. STUDY DESIGN: Cross-sectional study. METHODS: A total of 227 inpatients fulfilling the DSM-IV TR criteria for schizophrenia participated in the study. Demographic data including age, disease duration and medication intake were obtained. The Abnormal Involuntary Movement Scale (AIMS) and Simpson Angus Rating Scale (SARS) were performed on all patients. Odds of developing TD in relation to the different variables were computed. The association between study variables and development of TD was also evaluated using the Chi-square test. FINDINGS: Our cohort of patients had a mean age of 40 (range: 19-73 years old), had a mean disease duration of 6 years, had a daily neuroleptic dose of 700 mg in chlorpromazine equivalent, and had a lifetime neuroleptic exposure of at least 5 years. The prevalence rate of TD was 20.3% (46 out of 227 patients). Fifty-three percent of patients had significant extrapyramidal features (SARS > or =3). TD was noted more in females and older age groups. The other factors associated with TD: were those patients with longer duration of illness and those patients with longer cumulative exposure to neuroleptic drugs. There was no association found with regard to the presence of diabetes mellitus type II, to the use of anticholinergic drugs, to the history of substance abuse and to the history of electroconvulsive therapy. CONCLUSIONS: Despite the predominant use of first-generation antipsychotic agents, the prevalence of TD among Filipino schizophrenic patients is similar to that reported among Asians, but lower than that reported among our Western counterparts. The results may be affected by differences in methodological, racial and genetic determinants. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/19346155/The_current_prevalence_and_factors_associated_with_tardive_dyskinesia_among_Filipino_schizophrenic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(09)00060-1 DB - PRIME DP - Unbound Medicine ER -