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Monkeypox or varicella? Lessons from a rash outbreak investigation in the Republic of the Congo.
Am J Trop Med Hyg. 2009 Apr; 80(4):503-7.AJ

Abstract

Monkeypox virus and varicellazoster virus (VZV) cause visually similar rash illnesses. Monkeypox is more virulent, with fatality rates up to 10%. In June 2007, reports were received of a rash illness outbreak in isolated villages in Likouala district, Republic of the Congo. Blood specimens were obtained from 142 individuals reporting rash illness between January and September 2007 from four villages in Likouala. Thirty-seven cases of probable VZV were identified based on low VZV IgG avidity; cases occurred in all four villages. No probable monkeypox cases with orthopoxvirus-positive IgM responses were observed; however, three possible monkeypox cases, in individuals < 26 years of age, with rash illness occurring > 56 days before sampling and positive orthopoxvirus-specific IgG responses, were identified. Remoteness and delays in reporting limited collection of acute diagnostic specimens. Improvements in rash illness surveillance and infection control, through training of health workers and timely acquisition of diagnostic specimens, are being undertaken.

Authors+Show Affiliations

Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. aho3@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

19346366

Citation

MacNeil, Adam, et al. "Monkeypox or Varicella? Lessons From a Rash Outbreak Investigation in the Republic of the Congo." The American Journal of Tropical Medicine and Hygiene, vol. 80, no. 4, 2009, pp. 503-7.
MacNeil A, Reynolds MG, Carroll DS, et al. Monkeypox or varicella? Lessons from a rash outbreak investigation in the Republic of the Congo. Am J Trop Med Hyg. 2009;80(4):503-7.
MacNeil, A., Reynolds, M. G., Carroll, D. S., Karem, K., Braden, Z., Lash, R., Moundeli, A., Mombouli, J. V., Jumaan, A. O., Schmid, D. S., & Damon, I. K. (2009). Monkeypox or varicella? Lessons from a rash outbreak investigation in the Republic of the Congo. The American Journal of Tropical Medicine and Hygiene, 80(4), 503-7.
MacNeil A, et al. Monkeypox or Varicella? Lessons From a Rash Outbreak Investigation in the Republic of the Congo. Am J Trop Med Hyg. 2009;80(4):503-7. PubMed PMID: 19346366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monkeypox or varicella? Lessons from a rash outbreak investigation in the Republic of the Congo. AU - MacNeil,Adam, AU - Reynolds,Mary G, AU - Carroll,Darin S, AU - Karem,Kevin, AU - Braden,Zach, AU - Lash,Ryan, AU - Moundeli,Amba, AU - Mombouli,Jean-Vivien, AU - Jumaan,Aisha O, AU - Schmid,D Scott, AU - Damon,Inger K, PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2009/4/29/medline SP - 503 EP - 7 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 80 IS - 4 N2 - Monkeypox virus and varicellazoster virus (VZV) cause visually similar rash illnesses. Monkeypox is more virulent, with fatality rates up to 10%. In June 2007, reports were received of a rash illness outbreak in isolated villages in Likouala district, Republic of the Congo. Blood specimens were obtained from 142 individuals reporting rash illness between January and September 2007 from four villages in Likouala. Thirty-seven cases of probable VZV were identified based on low VZV IgG avidity; cases occurred in all four villages. No probable monkeypox cases with orthopoxvirus-positive IgM responses were observed; however, three possible monkeypox cases, in individuals < 26 years of age, with rash illness occurring > 56 days before sampling and positive orthopoxvirus-specific IgG responses, were identified. Remoteness and delays in reporting limited collection of acute diagnostic specimens. Improvements in rash illness surveillance and infection control, through training of health workers and timely acquisition of diagnostic specimens, are being undertaken. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/19346366/Monkeypox_or_varicella_Lessons_from_a_rash_outbreak_investigation_in_the_Republic_of_the_Congo_ L2 - http://www.diseaseinfosearch.org/result/4855 DB - PRIME DP - Unbound Medicine ER -