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Effects of amino acids supplement on physiological adaptations to resistance training.
Med Sci Sports Exerc. 2009 May; 41(5):1111-21.MS

Abstract

INTRODUCTION

Previous research has demonstrated that ingestion of essential amino acids and their metabolites induce anabolic effects with the potential to augment gains in lean body mass and strength after resistance exercise training.

PURPOSE

The purpose of the present study was to examine the effects of an essential amino acid-based formula (Muscle Armor (MA); Abbott Laboratories, Abbott Park, IL) containing beta-hydroxy-beta-methylbutyrate (HMB) on hormonal and muscle damage markers in response to 12 wk of resistance exercise.

METHODS

Seventeen healthy men (mean body mass: 77.9 +/- 7.2 kg; mean height: 174.3 +/- 12.4 cm; mean age: 22.9 +/- 3.8 yr) were matched and randomized into two groups and performed 12 wk of periodized heavy resistance training while supplementing with either MA or an isocaloric, isonitrogenous placebo (CON). Every 2 wk during the 12-wk intervention, resting blood draws were obtained, and muscle strength and power were measured. In addition, blood draws were obtained before, during, and after a standardized resistance exercise challenge performed pre-, mid-, and posttraining.

RESULTS

Lean body mass, muscle strength, and muscle power significantly (P <or= 0.05) increased in both groups after training; however, MA supplementation augmented these responses to a significantly greater extent when compared with the CON group. MA supplementation promoted increases in resting and exercise-induced testosterone and resting growth hormone concentrations. In addition, MA reduced preexercise cortisol concentrations. Throughout the training protocol, MA attenuated circulating creatine kinase and malondealdehyde compared with the CON group, suggesting that MA might have influenced a reduction in muscle damage.

CONCLUSION

MA supplementation beneficially affected training-induced changes in lean body mass, muscle strength, and power, as well as hormonal responses and markers of muscle damage in response to 12 wk of resistance exercise training when compared with an isonitrogenous control.

Authors+Show Affiliations

Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269-1110, USA. William.Kraemer@uconn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19346975

Citation

Kraemer, William J., et al. "Effects of Amino Acids Supplement On Physiological Adaptations to Resistance Training." Medicine and Science in Sports and Exercise, vol. 41, no. 5, 2009, pp. 1111-21.
Kraemer WJ, Hatfield DL, Volek JS, et al. Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc. 2009;41(5):1111-21.
Kraemer, W. J., Hatfield, D. L., Volek, J. S., Fragala, M. S., Vingren, J. L., Anderson, J. M., Spiering, B. A., Thomas, G. A., Ho, J. Y., Quann, E. E., Izquierdo, M., Häkkinen, K., & Maresh, C. M. (2009). Effects of amino acids supplement on physiological adaptations to resistance training. Medicine and Science in Sports and Exercise, 41(5), 1111-21. https://doi.org/10.1249/MSS.0b013e318194cc75
Kraemer WJ, et al. Effects of Amino Acids Supplement On Physiological Adaptations to Resistance Training. Med Sci Sports Exerc. 2009;41(5):1111-21. PubMed PMID: 19346975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of amino acids supplement on physiological adaptations to resistance training. AU - Kraemer,William J, AU - Hatfield,Disa L, AU - Volek,Jeff S, AU - Fragala,Maren S, AU - Vingren,Jakob L, AU - Anderson,Jeffrey M, AU - Spiering,Barry A, AU - Thomas,Gwendolyn A, AU - Ho,Jen Y, AU - Quann,Erin E, AU - Izquierdo,Mikel, AU - Häkkinen,Keijo, AU - Maresh,Carl M, PY - 2009/4/7/entrez PY - 2009/4/7/pubmed PY - 2009/9/9/medline SP - 1111 EP - 21 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 41 IS - 5 N2 - INTRODUCTION: Previous research has demonstrated that ingestion of essential amino acids and their metabolites induce anabolic effects with the potential to augment gains in lean body mass and strength after resistance exercise training. PURPOSE: The purpose of the present study was to examine the effects of an essential amino acid-based formula (Muscle Armor (MA); Abbott Laboratories, Abbott Park, IL) containing beta-hydroxy-beta-methylbutyrate (HMB) on hormonal and muscle damage markers in response to 12 wk of resistance exercise. METHODS: Seventeen healthy men (mean body mass: 77.9 +/- 7.2 kg; mean height: 174.3 +/- 12.4 cm; mean age: 22.9 +/- 3.8 yr) were matched and randomized into two groups and performed 12 wk of periodized heavy resistance training while supplementing with either MA or an isocaloric, isonitrogenous placebo (CON). Every 2 wk during the 12-wk intervention, resting blood draws were obtained, and muscle strength and power were measured. In addition, blood draws were obtained before, during, and after a standardized resistance exercise challenge performed pre-, mid-, and posttraining. RESULTS: Lean body mass, muscle strength, and muscle power significantly (P <or= 0.05) increased in both groups after training; however, MA supplementation augmented these responses to a significantly greater extent when compared with the CON group. MA supplementation promoted increases in resting and exercise-induced testosterone and resting growth hormone concentrations. In addition, MA reduced preexercise cortisol concentrations. Throughout the training protocol, MA attenuated circulating creatine kinase and malondealdehyde compared with the CON group, suggesting that MA might have influenced a reduction in muscle damage. CONCLUSION: MA supplementation beneficially affected training-induced changes in lean body mass, muscle strength, and power, as well as hormonal responses and markers of muscle damage in response to 12 wk of resistance exercise training when compared with an isonitrogenous control. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/19346975/Effects_of_amino_acids_supplement_on_physiological_adaptations_to_resistance_training_ L2 - http://dx.doi.org/10.1249/MSS.0b013e318194cc75 DB - PRIME DP - Unbound Medicine ER -