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Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model.
Exp Gerontol. 2009 Jun-Jul; 44(6-7):434-9.EG

Abstract

Pu-erh tea is believed to possess many beneficial health effects since it is a natural source of cardioprotective lipid lowering and antioxidant compounds, although, the major constituents putatively responsible for these beneficial effects remain unknown. In this study, we examined the effects of two commonly consumed forms of Pu-erh tea, fermented and unfermented, on weight gain, serum levels of lipids and lipoprotein, lipid oxidation, and blood antioxidant enzymes in a rat hyperlipidemia model. Hyperlipidemic rats were treated with water extracts of either 0.5, 1.5 or 3.0 mg/kg fermented or unfermented Pu-erh tea. Serum low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were significantly lowered by tea extract compared to the control group. (p < 0.05) and in most cases were indistinguishable from rats fed normal chow, basal diet. Conversely, levels of high density lipoprotein-cholesterol (HDL-C) were elevated in the groups given daily doses of tea extract (p < 0.05). Compared to the hyperlipidemic control group, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum were significantly elevated in Pu-erh tea-treated groups while levels of malondiadehyde (a byproduct of lipid peroxidation) decreased in the same groups. These effects were most pronounced in the groups treated with the highest dose of fermented Pu-erh tea extract. Our results suggest that Pu-erh tea exerts strong antioxidative and lipid-lowering effects and therefore can be used to reduce the risk of cardiovascular disorders.

Authors+Show Affiliations

Certificate Assessment Center of Yunnan Pu-erh Tea, Kunming, Yunnan 650201, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19348878

Citation

Hou, Yan, et al. "Pu-erh Tea Aqueous Extracts Lower Atherosclerotic Risk Factors in a Rat Hyperlipidemia Model." Experimental Gerontology, vol. 44, no. 6-7, 2009, pp. 434-9.
Hou Y, Shao W, Xiao R, et al. Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. Exp Gerontol. 2009;44(6-7):434-9.
Hou, Y., Shao, W., Xiao, R., Xu, K., Ma, Z., Johnstone, B. H., & Du, Y. (2009). Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. Experimental Gerontology, 44(6-7), 434-9. https://doi.org/10.1016/j.exger.2009.03.007
Hou Y, et al. Pu-erh Tea Aqueous Extracts Lower Atherosclerotic Risk Factors in a Rat Hyperlipidemia Model. Exp Gerontol. 2009 Jun-Jul;44(6-7):434-9. PubMed PMID: 19348878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. AU - Hou,Yan, AU - Shao,Wanfang, AU - Xiao,Rong, AU - Xu,Kunlong, AU - Ma,Zhizhong, AU - Johnstone,Brian H, AU - Du,Yansheng, Y1 - 2009/04/05/ PY - 2009/01/08/received PY - 2009/03/21/revised PY - 2009/03/26/accepted PY - 2009/4/8/entrez PY - 2009/4/8/pubmed PY - 2010/11/6/medline SP - 434 EP - 9 JF - Experimental gerontology JO - Exp Gerontol VL - 44 IS - 6-7 N2 - Pu-erh tea is believed to possess many beneficial health effects since it is a natural source of cardioprotective lipid lowering and antioxidant compounds, although, the major constituents putatively responsible for these beneficial effects remain unknown. In this study, we examined the effects of two commonly consumed forms of Pu-erh tea, fermented and unfermented, on weight gain, serum levels of lipids and lipoprotein, lipid oxidation, and blood antioxidant enzymes in a rat hyperlipidemia model. Hyperlipidemic rats were treated with water extracts of either 0.5, 1.5 or 3.0 mg/kg fermented or unfermented Pu-erh tea. Serum low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were significantly lowered by tea extract compared to the control group. (p < 0.05) and in most cases were indistinguishable from rats fed normal chow, basal diet. Conversely, levels of high density lipoprotein-cholesterol (HDL-C) were elevated in the groups given daily doses of tea extract (p < 0.05). Compared to the hyperlipidemic control group, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum were significantly elevated in Pu-erh tea-treated groups while levels of malondiadehyde (a byproduct of lipid peroxidation) decreased in the same groups. These effects were most pronounced in the groups treated with the highest dose of fermented Pu-erh tea extract. Our results suggest that Pu-erh tea exerts strong antioxidative and lipid-lowering effects and therefore can be used to reduce the risk of cardiovascular disorders. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/19348878/Pu_erh_tea_aqueous_extracts_lower_atherosclerotic_risk_factors_in_a_rat_hyperlipidemia_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(09)00062-X DB - PRIME DP - Unbound Medicine ER -