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Using a 308-nm excimer laser to treat vitiligo in Asians.

Abstract

BACKGROUND

Current vitiligo therapies require many months of treatment and often result in disappointing outcomes. Treatment with a 308-nm excimer laser has shown promising results in patients with vitiligo.

OBJECTIVE

This controlled prospective trial studied the effectiveness of the 308-nm excimer laser for treating vitiligo in Asians.

METHODS

Thirty-four patients (14 males and 20 females) with localized vitiligo were enrolled in the study. Vitiligo patches were treated using a 308-nm excimer laser. Lesions were treated twice weekly for 13 weeks. The treatment was started with 50 to 100 mJ/cm2 (according to site) and increased by 50 mJ/cm2 in every session until erythema appeared. Patients were treated for 25 sessions, or until 100% repigmentation, whichever was achieved first. The overall response rate was assessed clinically and by comparison of photographs before and after treatment by two independent investigators.

RESULTS

Twenty-nine patients (12 males and 17 females) completed the study. Lesions on the face responded better than elsewhere on the body. The least responsive areas were the hands and feet. The average number of treatment sessions prior to repigmentation was 11. Untreated control patches remained unchanged. In higher skin phototypes the response was more favorable. There was no significant correlation between the age of the patients and their response to treatment.

CONCLUSION

The use of the 308-nm excimer laser for the treatment of vitiligo is effective, relatively safe, and more convenient compared to other available modalities of treatment for stable vitiligo with small patches. However, similar to other modalities of treatment, the therapeutic effect is mainly dependent on the location of vitiligo lesions.

Authors+Show Affiliations

Department of Dermatology, Adan Hospital, P.O. Box 2193, Qurain 47372, Kuwait. dralotaibi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

19350183

Citation

Al-Otaibi, Sultan R., et al. "Using a 308-nm Excimer Laser to Treat Vitiligo in Asians." Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, vol. 18, no. 1, 2009, pp. 13-9.
Al-Otaibi SR, Zadeh VB, Al-Abdulrazzaq AH, et al. Using a 308-nm excimer laser to treat vitiligo in Asians. Acta Dermatovenerol Alp Pannonica Adriat. 2009;18(1):13-9.
Al-Otaibi, S. R., Zadeh, V. B., Al-Abdulrazzaq, A. H., Tarrab, S. M., Al-Owaidi, H. A., Mahrous, R., Kadyan, R. S., & Najem, N. M. (2009). Using a 308-nm excimer laser to treat vitiligo in Asians. Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica, 18(1), 13-9.
Al-Otaibi SR, et al. Using a 308-nm Excimer Laser to Treat Vitiligo in Asians. Acta Dermatovenerol Alp Pannonica Adriat. 2009;18(1):13-9. PubMed PMID: 19350183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using a 308-nm excimer laser to treat vitiligo in Asians. AU - Al-Otaibi,Sultan R, AU - Zadeh,Valid Bagher, AU - Al-Abdulrazzaq,Adel H, AU - Tarrab,Sahar M, AU - Al-Owaidi,Hesham A, AU - Mahrous,Rahma, AU - Kadyan,Randhir S, AU - Najem,Nabeel M, PY - 2009/4/8/entrez PY - 2009/4/8/pubmed PY - 2009/5/29/medline SP - 13 EP - 9 JF - Acta dermatovenerologica Alpina, Pannonica, et Adriatica JO - Acta Dermatovenerol Alp Pannonica Adriat VL - 18 IS - 1 N2 - BACKGROUND: Current vitiligo therapies require many months of treatment and often result in disappointing outcomes. Treatment with a 308-nm excimer laser has shown promising results in patients with vitiligo. OBJECTIVE: This controlled prospective trial studied the effectiveness of the 308-nm excimer laser for treating vitiligo in Asians. METHODS: Thirty-four patients (14 males and 20 females) with localized vitiligo were enrolled in the study. Vitiligo patches were treated using a 308-nm excimer laser. Lesions were treated twice weekly for 13 weeks. The treatment was started with 50 to 100 mJ/cm2 (according to site) and increased by 50 mJ/cm2 in every session until erythema appeared. Patients were treated for 25 sessions, or until 100% repigmentation, whichever was achieved first. The overall response rate was assessed clinically and by comparison of photographs before and after treatment by two independent investigators. RESULTS: Twenty-nine patients (12 males and 17 females) completed the study. Lesions on the face responded better than elsewhere on the body. The least responsive areas were the hands and feet. The average number of treatment sessions prior to repigmentation was 11. Untreated control patches remained unchanged. In higher skin phototypes the response was more favorable. There was no significant correlation between the age of the patients and their response to treatment. CONCLUSION: The use of the 308-nm excimer laser for the treatment of vitiligo is effective, relatively safe, and more convenient compared to other available modalities of treatment for stable vitiligo with small patches. However, similar to other modalities of treatment, the therapeutic effect is mainly dependent on the location of vitiligo lesions. SN - 1318-4458 UR - https://www.unboundmedicine.com/medline/citation/19350183/Using_a_308_nm_excimer_laser_to_treat_vitiligo_in_Asians_ L2 - http://s3-eu-west-1.amazonaws.com/thejournalhub/10.15570/archive/acta-apa-09-1/3.pdf DB - PRIME DP - Unbound Medicine ER -