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Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997-2003.
Birth Defects Res A Clin Mol Teratol. 2009 Sep; 85(9):773-9.BD

Abstract

BACKGROUND

The association between periconceptional intake of supplements containing folic acid with specific subtypes of limb deficiencies has been inconsistent. The objective was to investigate whether intake of nutrients involved in one-carbon metabolism (folate, vitamin B(6), vitamin B(12), riboflavin, choline, betaine, zinc, and methionine) through diet alone or in combination with a supplement containing folic acid influenced the risk for transverse limb deficiency (TLD) and longitudinal limb deficiency (LLD).

METHODS

We analyzed 1997-2003 data from the National Birth Defects Prevention Study and included 324 case infants with TLD, 158 case infants with LLD, and 4982 nonmalformed control infants. A food frequency questionnaire was used to estimate nutrient intakes. Use of supplements containing folic acid 1 month before through 2 months after conception was recorded.

RESULTS

Use of a supplement containing folic acid was not associated with LLD or TLD. For nonsupplement users, within (1) the lowest quartile of dietary folate intake or vitamin B(6) intake, adjusted odds ratios (aORs) for LLD were, respectively, 3.86 (95% confidence interval [CI]: 1.08-13.78) and 4.36 (95% CI: 0.93-20.48); and (2) the lowest quartile for riboflavin intake, the aOR for TLD was 2.94 (95% CI: 1.04-8.32). For supplement users within the lowest quartile of folate intake or riboflavin intake, the aORs for TLD were, respectively, 1.52 (95% CI: 0.91-2.54) and 1.54 (95% CI: 1.00-2.37).

CONCLUSIONS

TLD and LLD were not associated with supplement use, but TLD was associated with low intakes of riboflavin from diet.

Authors+Show Affiliations

National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

19350655

Citation

Robitaille, Julie, et al. "Maternal Nutrient Intake and Risks for Transverse and Longitudinal Limb Deficiencies: Data From the National Birth Defects Prevention Study, 1997-2003." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 85, no. 9, 2009, pp. 773-9.
Robitaille J, Carmichael SL, Shaw GM, et al. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997-2003. Birth Defects Res Part A Clin Mol Teratol. 2009;85(9):773-9.
Robitaille, J., Carmichael, S. L., Shaw, G. M., & Olney, R. S. (2009). Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997-2003. Birth Defects Research. Part A, Clinical and Molecular Teratology, 85(9), 773-9. https://doi.org/10.1002/bdra.20587
Robitaille J, et al. Maternal Nutrient Intake and Risks for Transverse and Longitudinal Limb Deficiencies: Data From the National Birth Defects Prevention Study, 1997-2003. Birth Defects Res Part A Clin Mol Teratol. 2009;85(9):773-9. PubMed PMID: 19350655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997-2003. AU - Robitaille,Julie, AU - Carmichael,Suzan L, AU - Shaw,Gary M, AU - Olney,Richard S, AU - ,, PY - 2009/4/8/entrez PY - 2009/4/8/pubmed PY - 2009/11/18/medline SP - 773 EP - 9 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res. Part A Clin. Mol. Teratol. VL - 85 IS - 9 N2 - BACKGROUND: The association between periconceptional intake of supplements containing folic acid with specific subtypes of limb deficiencies has been inconsistent. The objective was to investigate whether intake of nutrients involved in one-carbon metabolism (folate, vitamin B(6), vitamin B(12), riboflavin, choline, betaine, zinc, and methionine) through diet alone or in combination with a supplement containing folic acid influenced the risk for transverse limb deficiency (TLD) and longitudinal limb deficiency (LLD). METHODS: We analyzed 1997-2003 data from the National Birth Defects Prevention Study and included 324 case infants with TLD, 158 case infants with LLD, and 4982 nonmalformed control infants. A food frequency questionnaire was used to estimate nutrient intakes. Use of supplements containing folic acid 1 month before through 2 months after conception was recorded. RESULTS: Use of a supplement containing folic acid was not associated with LLD or TLD. For nonsupplement users, within (1) the lowest quartile of dietary folate intake or vitamin B(6) intake, adjusted odds ratios (aORs) for LLD were, respectively, 3.86 (95% confidence interval [CI]: 1.08-13.78) and 4.36 (95% CI: 0.93-20.48); and (2) the lowest quartile for riboflavin intake, the aOR for TLD was 2.94 (95% CI: 1.04-8.32). For supplement users within the lowest quartile of folate intake or riboflavin intake, the aORs for TLD were, respectively, 1.52 (95% CI: 0.91-2.54) and 1.54 (95% CI: 1.00-2.37). CONCLUSIONS: TLD and LLD were not associated with supplement use, but TLD was associated with low intakes of riboflavin from diet. SN - 1542-0760 UR - https://www.unboundmedicine.com/medline/citation/19350655/Maternal_nutrient_intake_and_risks_for_transverse_and_longitudinal_limb_deficiencies:_data_from_the_National_Birth_Defects_Prevention_Study_1997_2003_ L2 - https://doi.org/10.1002/bdra.20587 DB - PRIME DP - Unbound Medicine ER -