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Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin 3-O-galactoside, and its metabolites.
J Agric Food Chem. 2009 May 27; 57(10):4447-51.JA

Abstract

In vitro trials have indicated various potential health effects of lingonberries (Vaccinium vitis-idaea L.). Most of these studies have been performed with berry extract or juice, and the detailed chemical structures of active compounds in these products have not been elucidated. Lingonberry contains cyanidin-3-galactoside as its main anthocyanin. Absorption and metabolism of the compound is not fully understood, and no studies of anthocyanin metabolism have been performed with lingonberries. The aim of this study was to investigate the urinary excretion of cyanidin-3-galactoside and its metabolites in young and healthy subjects receiving a breakfast containing 300 g of lingonberries. A fast, selective, and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometric (uHPLC-MS/MS) method was optimized for the analysis of the anthocyanin metabolites in urine. Both intact cyanidin-3-galactoside and its methylated and glucuronidated metabolites were identified from urine samples. The two metabolites represented >50% of cyanidin excreted in urine. Maximal excretion appeared between 4 and 8 h after the meal. Also, the compounds were absorbed more slowly than reported previously in several studies.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lehtonen HM
Department of Biochemistry and Food Chemistry, University of Turku, Turku FI-20014, Finland. henna-maria.lehtonen@utu.fi
Rantala M
No affiliation info available
Suomela JP
No affiliation info available
Viitanen M
No affiliation info available
Kallio H
No affiliation info available

MeSH

AdultAnthocyaninsChromatography, High Pressure LiquidFemaleFruitGalactosidesHumansMaleTandem Mass SpectrometryVaccinium vitis-idaea

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19351112

Citation

Lehtonen, Henna-Maria, et al. "Urinary Excretion of the Main Anthocyanin in Lingonberry (Vaccinium Vitis-idaea), Cyanidin 3-O-galactoside, and Its Metabolites." Journal of Agricultural and Food Chemistry, vol. 57, no. 10, 2009, pp. 4447-51.
Lehtonen HM, Rantala M, Suomela JP, et al. Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin 3-O-galactoside, and its metabolites. J Agric Food Chem. 2009;57(10):4447-51.
Lehtonen, H. M., Rantala, M., Suomela, J. P., Viitanen, M., & Kallio, H. (2009). Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin 3-O-galactoside, and its metabolites. Journal of Agricultural and Food Chemistry, 57(10), 4447-51. https://doi.org/10.1021/jf900894k
Lehtonen HM, et al. Urinary Excretion of the Main Anthocyanin in Lingonberry (Vaccinium Vitis-idaea), Cyanidin 3-O-galactoside, and Its Metabolites. J Agric Food Chem. 2009 May 27;57(10):4447-51. PubMed PMID: 19351112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary excretion of the main anthocyanin in lingonberry (Vaccinium vitis-idaea), cyanidin 3-O-galactoside, and its metabolites. AU - Lehtonen,Henna-Maria, AU - Rantala,Milla, AU - Suomela,Jukka-Pekka, AU - Viitanen,Matti, AU - Kallio,Heikki, Y1 - 2009/04/07/ PY - 2009/4/9/entrez PY - 2009/4/9/pubmed PY - 2011/5/25/medline SP - 4447 EP - 51 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 57 IS - 10 N2 - In vitro trials have indicated various potential health effects of lingonberries (Vaccinium vitis-idaea L.). Most of these studies have been performed with berry extract or juice, and the detailed chemical structures of active compounds in these products have not been elucidated. Lingonberry contains cyanidin-3-galactoside as its main anthocyanin. Absorption and metabolism of the compound is not fully understood, and no studies of anthocyanin metabolism have been performed with lingonberries. The aim of this study was to investigate the urinary excretion of cyanidin-3-galactoside and its metabolites in young and healthy subjects receiving a breakfast containing 300 g of lingonberries. A fast, selective, and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometric (uHPLC-MS/MS) method was optimized for the analysis of the anthocyanin metabolites in urine. Both intact cyanidin-3-galactoside and its methylated and glucuronidated metabolites were identified from urine samples. The two metabolites represented >50% of cyanidin excreted in urine. Maximal excretion appeared between 4 and 8 h after the meal. Also, the compounds were absorbed more slowly than reported previously in several studies. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/19351112/Urinary_excretion_of_the_main_anthocyanin_in_lingonberry__Vaccinium_vitis_idaea__cyanidin_3_O_galactoside_and_its_metabolites_ L2 - https://doi.org/10.1021/jf900894k DB - PRIME DP - Unbound Medicine ER -