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A dose-response study of the effects of pre-test administration of beta-adrenergic receptor antagonist propranolol on the learning of active place avoidance, a spatial cognition task, in rats.
Behav Brain Res. 2009 Jun 08; 200(1):144-9.BB

Abstract

The involvement of various neurotransmitter receptors in the brain in the regulation of spatial behavior is a focus of interest for many cognitive neuroscientists. Active allothetic place avoidance (AAPA) task have been demonstrated to require spatial mapping and cognitive coordination and is highly dependent upon hippocampus. The present study was designed to evaluate the role of beta-adrenergic receptors in the modulation of locomotor and spatial behavior in this task. Four doses of centrally active beta-adrenergic antagonist propranolol (5, 20, 25 and 30 mg/kg) were administered intraperitoneally 30 min prior to testing in the place avoidance task. Four daily sessions were pursued, each lasting 20 min. A dose of 25 mg/kg was found to induce a deficit in spatial behavior (measured by number of entrances into the shock sector) without altering locomotion; lower doses were without effect. The highest dose (30 mg/kg) impaired both locomotion and avoidance behavior. The results suggest that beta-adrenoceptors are involved in the regulation of behavior in the place avoidance task and that it is possible to dissociate the effect of propranolol on the spatial performance and locomotion in the AAPA using dose-selection.

Authors+Show Affiliations

Institute of Physiology, Academy of Sciences of Czech Republic, v.v.i., Videnska 1083, 14220 Prague 4, Czech Republic. stuchlik@biomed.cas.czNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19351584

Citation

Stuchlik, Ales, et al. "A Dose-response Study of the Effects of Pre-test Administration of Beta-adrenergic Receptor Antagonist Propranolol On the Learning of Active Place Avoidance, a Spatial Cognition Task, in Rats." Behavioural Brain Research, vol. 200, no. 1, 2009, pp. 144-9.
Stuchlik A, Petrasek T, Vales K. A dose-response study of the effects of pre-test administration of beta-adrenergic receptor antagonist propranolol on the learning of active place avoidance, a spatial cognition task, in rats. Behav Brain Res. 2009;200(1):144-9.
Stuchlik, A., Petrasek, T., & Vales, K. (2009). A dose-response study of the effects of pre-test administration of beta-adrenergic receptor antagonist propranolol on the learning of active place avoidance, a spatial cognition task, in rats. Behavioural Brain Research, 200(1), 144-9. https://doi.org/10.1016/j.bbr.2009.01.010
Stuchlik A, Petrasek T, Vales K. A Dose-response Study of the Effects of Pre-test Administration of Beta-adrenergic Receptor Antagonist Propranolol On the Learning of Active Place Avoidance, a Spatial Cognition Task, in Rats. Behav Brain Res. 2009 Jun 8;200(1):144-9. PubMed PMID: 19351584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A dose-response study of the effects of pre-test administration of beta-adrenergic receptor antagonist propranolol on the learning of active place avoidance, a spatial cognition task, in rats. AU - Stuchlik,Ales, AU - Petrasek,Tomas, AU - Vales,Karel, Y1 - 2009/01/15/ PY - 2008/10/26/received PY - 2009/01/06/revised PY - 2009/01/07/accepted PY - 2009/4/9/entrez PY - 2009/4/9/pubmed PY - 2009/6/19/medline SP - 144 EP - 9 JF - Behavioural brain research JO - Behav Brain Res VL - 200 IS - 1 N2 - The involvement of various neurotransmitter receptors in the brain in the regulation of spatial behavior is a focus of interest for many cognitive neuroscientists. Active allothetic place avoidance (AAPA) task have been demonstrated to require spatial mapping and cognitive coordination and is highly dependent upon hippocampus. The present study was designed to evaluate the role of beta-adrenergic receptors in the modulation of locomotor and spatial behavior in this task. Four doses of centrally active beta-adrenergic antagonist propranolol (5, 20, 25 and 30 mg/kg) were administered intraperitoneally 30 min prior to testing in the place avoidance task. Four daily sessions were pursued, each lasting 20 min. A dose of 25 mg/kg was found to induce a deficit in spatial behavior (measured by number of entrances into the shock sector) without altering locomotion; lower doses were without effect. The highest dose (30 mg/kg) impaired both locomotion and avoidance behavior. The results suggest that beta-adrenoceptors are involved in the regulation of behavior in the place avoidance task and that it is possible to dissociate the effect of propranolol on the spatial performance and locomotion in the AAPA using dose-selection. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/19351584/A_dose_response_study_of_the_effects_of_pre_test_administration_of_beta_adrenergic_receptor_antagonist_propranolol_on_the_learning_of_active_place_avoidance_a_spatial_cognition_task_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(09)00034-5 DB - PRIME DP - Unbound Medicine ER -