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Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major.
Panminerva Med 2009; 51(1):17-23PM

Abstract

Osteoporosis represents an important cause of morbidity in thalassaemia major patients; the etiopathogenesis is multifactorial and includes expansion of the bone marrow, endocrine disorders, iron overload and genetic factors. Two cytokines, osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL), have recently been identified as important mediators in the pathogenesis of osteoporosis. In this study, the possible role of the OPG-RANKL system in the pathogenesis of osteoporosis in thalassemia major is assessed, as well as any correlations between the serum levels of OPG and RANKL and bone mineral density (BMD), 17 beta-estradiol and free testosterone and the relationship between T-score of BMD and OPG/RANKL ratio. In 31 thalassaemia major patients and a control group, the serum values of OPG and RANKL were assayed and correlated with BMD, as well as with the sex hormones values. All the thalassemic patients had reduced BMD and 35.5% presented osteoporosis. The thalassemic patients had significantly higher serum levels of OPG than the controls, while their higher RANKL levels, were at the threshold of significance. The OPG/RANKL ratio showed higher level respect to the controls. No statistically significant correlation was observed between the T-score and RANKL neither between the T-score and OPG nor between T-score and OPG/RANKL ratio. Instead, a statistically significant correlation was found between the T-score and free testosterone and between the T-score and 17 beta-estradiol. There was no correlation between the sex hormones and OPG and RANKL. The increased OPG values in thalassemic patients could be considered to compensate the increased bone turnover. The authors confirm hypogonadism as a primary etiopathogenetic factor in the reduced BMD observed in thalassaemia major patients.

Authors+Show Affiliations

Unit of Hematology, University of Bari, Bari, Italy. a.pietrapertosa@emat2.uniba.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19352306

Citation

Pietrapertosa, A C., et al. "Osteoprotegerin and RANKL in the Pathogenesis of Osteoporosis in Patients With Thalassaemia Major." Panminerva Medica, vol. 51, no. 1, 2009, pp. 17-23.
Pietrapertosa AC, Minenna G, Colella SM, et al. Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major. Panminerva Med. 2009;51(1):17-23.
Pietrapertosa, A. C., Minenna, G., Colella, S. M., Santeramo, T. M., Renni, R., & D'Amore, M. (2009). Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major. Panminerva Medica, 51(1), pp. 17-23.
Pietrapertosa AC, et al. Osteoprotegerin and RANKL in the Pathogenesis of Osteoporosis in Patients With Thalassaemia Major. Panminerva Med. 2009;51(1):17-23. PubMed PMID: 19352306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoprotegerin and RANKL in the pathogenesis of osteoporosis in patients with thalassaemia major. AU - Pietrapertosa,A C, AU - Minenna,G, AU - Colella,S M, AU - Santeramo,T M, AU - Renni,R, AU - D'Amore,M, PY - 2009/4/9/entrez PY - 2009/4/9/pubmed PY - 2009/7/25/medline SP - 17 EP - 23 JF - Panminerva medica JO - Panminerva Med VL - 51 IS - 1 N2 - Osteoporosis represents an important cause of morbidity in thalassaemia major patients; the etiopathogenesis is multifactorial and includes expansion of the bone marrow, endocrine disorders, iron overload and genetic factors. Two cytokines, osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL), have recently been identified as important mediators in the pathogenesis of osteoporosis. In this study, the possible role of the OPG-RANKL system in the pathogenesis of osteoporosis in thalassemia major is assessed, as well as any correlations between the serum levels of OPG and RANKL and bone mineral density (BMD), 17 beta-estradiol and free testosterone and the relationship between T-score of BMD and OPG/RANKL ratio. In 31 thalassaemia major patients and a control group, the serum values of OPG and RANKL were assayed and correlated with BMD, as well as with the sex hormones values. All the thalassemic patients had reduced BMD and 35.5% presented osteoporosis. The thalassemic patients had significantly higher serum levels of OPG than the controls, while their higher RANKL levels, were at the threshold of significance. The OPG/RANKL ratio showed higher level respect to the controls. No statistically significant correlation was observed between the T-score and RANKL neither between the T-score and OPG nor between T-score and OPG/RANKL ratio. Instead, a statistically significant correlation was found between the T-score and free testosterone and between the T-score and 17 beta-estradiol. There was no correlation between the sex hormones and OPG and RANKL. The increased OPG values in thalassemic patients could be considered to compensate the increased bone turnover. The authors confirm hypogonadism as a primary etiopathogenetic factor in the reduced BMD observed in thalassaemia major patients. SN - 1827-1898 UR - https://www.unboundmedicine.com/medline/citation/19352306/Osteoprotegerin_and_RANKL_in_the_pathogenesis_of_osteoporosis_in_patients_with_thalassaemia_major_ L2 - http://www.minervamedica.it/index2.t?show=R41Y2009N01A0017 DB - PRIME DP - Unbound Medicine ER -