Abstract
OBJECTIVE
To evaluate the long-term effects on bone mineral density (BMD) in women diagnosed with menstrual disorders in their adolescence.
DESIGN
Prospective follow-up study six years after the initial investigation.
SETTING
A youth clinic that is part of the school health system in Stockholm.
POPULATION
Eighty-seven women diagnosed with secondary amenorrhea or oligomenorrhea in adolescence.
METHODS
Subjects underwent gynecological examination, evaluation of eating behavior and physical activity. Whole body Dual Energy X-ray Absorptiometry was used for measurement of BMD.
MAIN OUTCOME MEASURES
BMD.
RESULTS
The overall frequency of osteopenia/osteoporosis was 52%, and three girls had osteoporosis. Women with previous secondary amenorrhea had significantly lower BMD in the pelvis and lumbar spine than those with previous oligomenorrhea. The strongest predictor of low BMD was a restrictive eating disorder in adolescence and the most important counteraction was high physical activity at follow-up and a body mass index (BMI) > or = 22. Persistent menstrual dysfunction at follow-up was associated with polycystic ovary syndrome and lower frequency of osteopenia.
CONCLUSIONS
This clinical follow-up study has demonstrated a high frequency of osteopenia in women diagnosed with menstrual disorders in adolescence. Previous anorectic behavior was the strongest negative predictor of BMD. It is important to pay attention to an underlying eating disorder in young women with menstrual dysfunction in order to promote bone health.
TY - JOUR
T1 - Reduced bone mineral density in adult women diagnosed with menstrual disorders during adolescence.
AU - Wiksten-Almströmer,Marianne,
AU - Hirschberg,Angelica Lindën,
AU - Hagenfeldt,Kerstin,
PY - 2009/4/9/entrez
PY - 2009/4/9/pubmed
PY - 2009/5/21/medline
SP - 543
EP - 9
JF - Acta obstetricia et gynecologica Scandinavica
JO - Acta Obstet Gynecol Scand
VL - 88
IS - 5
N2 - OBJECTIVE: To evaluate the long-term effects on bone mineral density (BMD) in women diagnosed with menstrual disorders in their adolescence. DESIGN: Prospective follow-up study six years after the initial investigation. SETTING: A youth clinic that is part of the school health system in Stockholm. POPULATION: Eighty-seven women diagnosed with secondary amenorrhea or oligomenorrhea in adolescence. METHODS: Subjects underwent gynecological examination, evaluation of eating behavior and physical activity. Whole body Dual Energy X-ray Absorptiometry was used for measurement of BMD. MAIN OUTCOME MEASURES: BMD. RESULTS: The overall frequency of osteopenia/osteoporosis was 52%, and three girls had osteoporosis. Women with previous secondary amenorrhea had significantly lower BMD in the pelvis and lumbar spine than those with previous oligomenorrhea. The strongest predictor of low BMD was a restrictive eating disorder in adolescence and the most important counteraction was high physical activity at follow-up and a body mass index (BMI) > or = 22. Persistent menstrual dysfunction at follow-up was associated with polycystic ovary syndrome and lower frequency of osteopenia. CONCLUSIONS: This clinical follow-up study has demonstrated a high frequency of osteopenia in women diagnosed with menstrual disorders in adolescence. Previous anorectic behavior was the strongest negative predictor of BMD. It is important to pay attention to an underlying eating disorder in young women with menstrual dysfunction in order to promote bone health.
SN - 1600-0412
UR - https://www.unboundmedicine.com/medline/citation/19353333/Reduced_bone_mineral_density_in_adult_women_diagnosed_with_menstrual_disorders_during_adolescence_
L2 - https://doi.org/10.1080/00016340902846080
DB - PRIME
DP - Unbound Medicine
ER -
