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Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia.
Mov Disord. 2009 May 15; 24(7):1028-33.MD

Abstract

Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age- and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 micromol/L +/- 10.2 vs. 11 +/- 4.1; P < 0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 micromol/L +/- 12.1 vs. 15.8 +/- 8.5; P = 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 micromol/L) with the bottom tertile (<12.4 micromol/L): 3.68; 95% CI: 1.14-11.83] were significantly associated with dementia. These data support the association between elevated Hcy levels and the presence of dementia in PD.

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Authors+Show Affiliations

Zoccolella S
Clinic of Nervous System Diseases, Medical and Neurological Sciences, Azienda Ospedaliero-Universitaria Ospedali Riuniti, University of Foggia, Italy.
dell'Aquila C
No affiliation info available
Abruzzese G
No affiliation info available
Antonini A
No affiliation info available
Bonuccelli U
No affiliation info available
Canesi M
No affiliation info available
Cristina S
No affiliation info available
Marchese R
No affiliation info available
Pacchetti C
No affiliation info available
Zagaglia R
No affiliation info available
Logroscino G
No affiliation info available
Defazio G
No affiliation info available
Lamberti P
No affiliation info available
Livrea P
No affiliation info available

MeSH

AgedAnalysis of VarianceAntiparkinson AgentsCase-Control StudiesChromatography, High Pressure LiquidCross-Sectional StudiesDementiaFemaleHomocysteineHumansHyperhomocysteinemiaLevodopaLogistic ModelsMaleMental Status ScheduleMiddle AgedNeuropsychological TestsParkinson Disease

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

19353704

Citation

Zoccolella, Stefano, et al. "Hyperhomocysteinemia in Levodopa-treated Patients With Parkinson's Disease Dementia." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 24, no. 7, 2009, pp. 1028-33.
Zoccolella S, dell'Aquila C, Abruzzese G, et al. Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia. Mov Disord. 2009;24(7):1028-33.
Zoccolella, S., dell'Aquila, C., Abruzzese, G., Antonini, A., Bonuccelli, U., Canesi, M., Cristina, S., Marchese, R., Pacchetti, C., Zagaglia, R., Logroscino, G., Defazio, G., Lamberti, P., & Livrea, P. (2009). Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia. Movement Disorders : Official Journal of the Movement Disorder Society, 24(7), 1028-33. https://doi.org/10.1002/mds.22511
Zoccolella S, et al. Hyperhomocysteinemia in Levodopa-treated Patients With Parkinson's Disease Dementia. Mov Disord. 2009 May 15;24(7):1028-33. PubMed PMID: 19353704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia in levodopa-treated patients with Parkinson's disease dementia. AU - Zoccolella,Stefano, AU - dell'Aquila,Claudia, AU - Abruzzese,Giovanni, AU - Antonini,Angelo, AU - Bonuccelli,Ubaldo, AU - Canesi,Margherita, AU - Cristina,Silvano, AU - Marchese,Roberta, AU - Pacchetti,Claudio, AU - Zagaglia,Roberto, AU - Logroscino,Giancarlo, AU - Defazio,Giovanni, AU - Lamberti,Paolo, AU - Livrea,Paolo, PY - 2009/4/9/entrez PY - 2009/4/9/pubmed PY - 2009/8/20/medline SP - 1028 EP - 33 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 24 IS - 7 N2 - Dementia is a frequent non-motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa-treated patients with PD. The objective of our study was to evaluate the association between plasma Hcy levels and dementia in PD. We performed a multicenter cross-sectional study on patients with PD with (PDD) and without (PDnD) dementia and age- and sex-matched healthy controls. We compared Hcy levels in patients with PDD and PDnD and healthy controls, and we performed logistic regression analysis to search for an association between the presence of dementia and increased Hcy levels in PD. Patients with PD (121), PDD (42), and PDnD (79), and age- and sex-matched controls (154) were enrolled. Hcy levels were higher in patients with PD compared to controls (17.5 micromol/L +/- 10.2 vs. 11 +/- 4.1; P < 0.00001). Among patients with PD, Hcy levels were higher in the PDD group compared to the PDnD group (20.7 micromol/L +/- 12.1 vs. 15.8 +/- 8.5; P = 0.002). In a multivariate logistic regression model, higher Hcy levels [Odds ratios comparing the top (>18.9 micromol/L) with the bottom tertile (<12.4 micromol/L): 3.68; 95% CI: 1.14-11.83] were significantly associated with dementia. These data support the association between elevated Hcy levels and the presence of dementia in PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/19353704/Hyperhomocysteinemia_in_levodopa_treated_patients_with_Parkinson's_disease_dementia_ L2 - https://doi.org/10.1002/mds.22511 DB - PRIME DP - Unbound Medicine ER -