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Effects of blackberries on motor and cognitive function in aged rats.
Nutr Neurosci. 2009 Jun; 12(3):135-40.NN

Abstract

The polyphenolics in fruits and vegetables, when fed to rats from 19-21 months of age, have been shown to retard and even reverse age-related decrements in motor and cognitive performance. These effects may be the result of the polyphenols increasing antioxidant and/or anti-inflammatory levels, or by direct effects on signaling, in the brain. Increased dietary intake of berry fruit, in particular, has a positive and profound impact on human health, performance, and disease. Thus, the present study examined a 2% blackberry-supplemented diet for its effectiveness in reversing age-related deficits in behavioral and neuronal function when fed to aged (19-month-old) Fischer 344 rats for 8 weeks. The results showed that the blackberry diet improved motor performance on three tasks which rely on balance and co-ordination: the accelerating rotarod, wire suspension, and the small plank walk. Results for the Morris water maze showed that the blackberry-fed rats had significantly greater working, or short-term, memory performance than the control rats. These data support our previous investigations in which we have seen improved motor and cognitive performance in aged rats after supplementation with other berry fruits.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. barbara.shukitthale@ars.usda.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19356316

Citation

Shukitt-Hale, Barbara, et al. "Effects of Blackberries On Motor and Cognitive Function in Aged Rats." Nutritional Neuroscience, vol. 12, no. 3, 2009, pp. 135-40.
Shukitt-Hale B, Cheng V, Joseph JA. Effects of blackberries on motor and cognitive function in aged rats. Nutr Neurosci. 2009;12(3):135-40.
Shukitt-Hale, B., Cheng, V., & Joseph, J. A. (2009). Effects of blackberries on motor and cognitive function in aged rats. Nutritional Neuroscience, 12(3), 135-40. https://doi.org/10.1179/147683009X423292
Shukitt-Hale B, Cheng V, Joseph JA. Effects of Blackberries On Motor and Cognitive Function in Aged Rats. Nutr Neurosci. 2009;12(3):135-40. PubMed PMID: 19356316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of blackberries on motor and cognitive function in aged rats. AU - Shukitt-Hale,Barbara, AU - Cheng,Vivian, AU - Joseph,James A, PY - 2009/4/10/entrez PY - 2009/4/10/pubmed PY - 2009/6/6/medline SP - 135 EP - 40 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 12 IS - 3 N2 - The polyphenolics in fruits and vegetables, when fed to rats from 19-21 months of age, have been shown to retard and even reverse age-related decrements in motor and cognitive performance. These effects may be the result of the polyphenols increasing antioxidant and/or anti-inflammatory levels, or by direct effects on signaling, in the brain. Increased dietary intake of berry fruit, in particular, has a positive and profound impact on human health, performance, and disease. Thus, the present study examined a 2% blackberry-supplemented diet for its effectiveness in reversing age-related deficits in behavioral and neuronal function when fed to aged (19-month-old) Fischer 344 rats for 8 weeks. The results showed that the blackberry diet improved motor performance on three tasks which rely on balance and co-ordination: the accelerating rotarod, wire suspension, and the small plank walk. Results for the Morris water maze showed that the blackberry-fed rats had significantly greater working, or short-term, memory performance than the control rats. These data support our previous investigations in which we have seen improved motor and cognitive performance in aged rats after supplementation with other berry fruits. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/19356316/Effects_of_blackberries_on_motor_and_cognitive_function_in_aged_rats_ L2 - https://www.tandfonline.com/doi/full/10.1179/147683009X423292 DB - PRIME DP - Unbound Medicine ER -