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Levels of inflammatory markers and their correlation with dyslipidemia in diabetics.
J Coll Physicians Surg Pak. 2009 Apr; 19(4):207-10.JC

Abstract

OBJECTIVE

To measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia.

STUDY DESIGN

Comparative study.

PLACE AND DURATION OF STUDY

Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, from March 2007 to February 2008.

METHODOLOGY

The study included 30 known type-2 diabetic patients randomly inducted from diabetic clinics of Rawalpindi. Healthy volunteers (n=30) having blood glucose less than 6 mmol/L were inducted as the comparison group. Fasting blood samples of diabetics and controls were analyzed for glucose, glycated hemoglobin (HbA1c), lipid profile, high sensitivity C-reactive protein (hs-CRP) and serum ferritin.

RESULTS

The diabetic subjects had significantly higher levels of glucose, HbA1c, total cholesterol, LDL cholesterol, triglycerides, hs-CRP and ferritin as compared to normal subjects (p<0.001), while the level of HDL cholesterol was significantly lower in diabetics (p<0.001). Furthermore, a significant positive correlation was found between the inflammatory markers, hs-CRP and ferritin, and the parameters of dyslipidemia i.e. total cholesterol, LDL cholesterol and triglycerides (p<0.001 r=0.72) except for HDL cholesterol, which had an insignificant negative correlation with the inflammatory markers (p>0.05 r=-0.10).

CONCLUSION

Low-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19356332

Citation

Waheed, Palvasha, et al. "Levels of Inflammatory Markers and Their Correlation With Dyslipidemia in Diabetics." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 19, no. 4, 2009, pp. 207-10.
Waheed P, Naveed AK, Farooq F. Levels of inflammatory markers and their correlation with dyslipidemia in diabetics. J Coll Physicians Surg Pak. 2009;19(4):207-10.
Waheed, P., Naveed, A. K., & Farooq, F. (2009). Levels of inflammatory markers and their correlation with dyslipidemia in diabetics. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 19(4), 207-10. https://doi.org/04.2009/JCPSP.207210
Waheed P, Naveed AK, Farooq F. Levels of Inflammatory Markers and Their Correlation With Dyslipidemia in Diabetics. J Coll Physicians Surg Pak. 2009;19(4):207-10. PubMed PMID: 19356332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of inflammatory markers and their correlation with dyslipidemia in diabetics. AU - Waheed,Palvasha, AU - Naveed,Abdul Khaliq, AU - Farooq,Fareeha, PY - 2008/05/17/received PY - 2009/01/26/accepted PY - 2009/4/10/entrez PY - 2009/4/10/pubmed PY - 2010/1/6/medline SP - 207 EP - 10 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 19 IS - 4 N2 - OBJECTIVE: To measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia. STUDY DESIGN: Comparative study. PLACE AND DURATION OF STUDY: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, from March 2007 to February 2008. METHODOLOGY: The study included 30 known type-2 diabetic patients randomly inducted from diabetic clinics of Rawalpindi. Healthy volunteers (n=30) having blood glucose less than 6 mmol/L were inducted as the comparison group. Fasting blood samples of diabetics and controls were analyzed for glucose, glycated hemoglobin (HbA1c), lipid profile, high sensitivity C-reactive protein (hs-CRP) and serum ferritin. RESULTS: The diabetic subjects had significantly higher levels of glucose, HbA1c, total cholesterol, LDL cholesterol, triglycerides, hs-CRP and ferritin as compared to normal subjects (p<0.001), while the level of HDL cholesterol was significantly lower in diabetics (p<0.001). Furthermore, a significant positive correlation was found between the inflammatory markers, hs-CRP and ferritin, and the parameters of dyslipidemia i.e. total cholesterol, LDL cholesterol and triglycerides (p<0.001 r=0.72) except for HDL cholesterol, which had an insignificant negative correlation with the inflammatory markers (p>0.05 r=-0.10). CONCLUSION: Low-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics. SN - 1022-386X UR - https://www.unboundmedicine.com/medline/citation/19356332/Levels_of_inflammatory_markers_and_their_correlation_with_dyslipidemia_in_diabetics_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -