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Vaspin and its correlation with insulin sensitivity indices in obese children.
Diabetes Res Clin Pract. 2009 Jun; 84(3):325-8.DR

Abstract

AIM

The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents.

MATERIAL AND METHODS

Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sensitivity and lipids were analyzed in 33 pubertal obese children (19 girls and 14 boys) and 36 healthy control children (18 girls and 18 boys) aged 11-16 years. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) and fasting glucose-to-insulin ratio (FGIR). Plasma vaspin and adiponectin concentrations were determined with radioimmunoassay.

RESULTS

Mean vaspin levels were found significantly higher and inversely, adiponectin levels were found significantly lower in obese pubertal group than control subjects. Vaspin levels were positively correlated with BMI-SDS, triglycerides, fasting insulin and HOMA-IR and negatively correlated with adiponectin levels and FGIR. Adiponectin levels were positively correlated with high density lipoprotein-chloesterol, FGIR and negatively correlated with vaspin, BMI-SDS, fasting insulin and HOMA-IR.

CONCLUSION

We found higher vaspin and lower adiponectin levels in obese children and these adipokines were significantly correlated with insulin sensitivity indices in this age.

Authors+Show Affiliations

Department of Pediatrics, GATA Medical Faculty, Istanbul, Turkey. rubina_k@msn.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19356820

Citation

Suleymanoglu, Selami, et al. "Vaspin and Its Correlation With Insulin Sensitivity Indices in Obese Children." Diabetes Research and Clinical Practice, vol. 84, no. 3, 2009, pp. 325-8.
Suleymanoglu S, Tascilar E, Pirgon O, et al. Vaspin and its correlation with insulin sensitivity indices in obese children. Diabetes Res Clin Pract. 2009;84(3):325-8.
Suleymanoglu, S., Tascilar, E., Pirgon, O., Tapan, S., Meral, C., & Abaci, A. (2009). Vaspin and its correlation with insulin sensitivity indices in obese children. Diabetes Research and Clinical Practice, 84(3), 325-8. https://doi.org/10.1016/j.diabres.2009.03.008
Suleymanoglu S, et al. Vaspin and Its Correlation With Insulin Sensitivity Indices in Obese Children. Diabetes Res Clin Pract. 2009;84(3):325-8. PubMed PMID: 19356820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaspin and its correlation with insulin sensitivity indices in obese children. AU - Suleymanoglu,Selami, AU - Tascilar,Emre, AU - Pirgon,Ozgur, AU - Tapan,Serkan, AU - Meral,Cihan, AU - Abaci,Ayhan, Y1 - 2009/04/07/ PY - 2008/12/04/received PY - 2009/03/07/revised PY - 2009/03/10/accepted PY - 2009/4/10/entrez PY - 2009/4/10/pubmed PY - 2009/9/17/medline SP - 325 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 84 IS - 3 N2 - AIM: The aim of this study was to assess the vaspin and adiponectin concentrations on markers of insulin sensitivity and obesity in pubertal obese children and adolescents. MATERIAL AND METHODS: Plasma vaspin and adiponectin level and its relationships with body mass index standard deviation score (BMI-SDS), insulin sensitivity and lipids were analyzed in 33 pubertal obese children (19 girls and 14 boys) and 36 healthy control children (18 girls and 18 boys) aged 11-16 years. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) and fasting glucose-to-insulin ratio (FGIR). Plasma vaspin and adiponectin concentrations were determined with radioimmunoassay. RESULTS: Mean vaspin levels were found significantly higher and inversely, adiponectin levels were found significantly lower in obese pubertal group than control subjects. Vaspin levels were positively correlated with BMI-SDS, triglycerides, fasting insulin and HOMA-IR and negatively correlated with adiponectin levels and FGIR. Adiponectin levels were positively correlated with high density lipoprotein-chloesterol, FGIR and negatively correlated with vaspin, BMI-SDS, fasting insulin and HOMA-IR. CONCLUSION: We found higher vaspin and lower adiponectin levels in obese children and these adipokines were significantly correlated with insulin sensitivity indices in this age. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/19356820/Vaspin_and_its_correlation_with_insulin_sensitivity_indices_in_obese_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(09)00123-5 DB - PRIME DP - Unbound Medicine ER -