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Diabetes preceding Parkinson's disease onset. A case-control study.
Parkinsonism Relat Disord. 2009 Nov; 15(9):660-4.PR

Abstract

OBJECTIVE

To assess the association between diabetes preceding Parkinson's disease (PD) and PD.

METHODS

PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption.

RESULTS

318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8).

CONCLUSIONS

Our findings provide additional support for a potential link between diabetes and PD.

Authors+Show Affiliations

Dipartimento Universitario di Neuroscienze Cliniche, Via Gaetano La Loggia 1, 90129 Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19356970

Citation

D'Amelio, Marco, et al. "Diabetes Preceding Parkinson's Disease Onset. a Case-control Study." Parkinsonism & Related Disorders, vol. 15, no. 9, 2009, pp. 660-4.
D'Amelio M, Ragonese P, Callari G, et al. Diabetes preceding Parkinson's disease onset. A case-control study. Parkinsonism Relat Disord. 2009;15(9):660-4.
D'Amelio, M., Ragonese, P., Callari, G., Di Benedetto, N., Palmeri, B., Terruso, V., Salemi, G., Famoso, G., Aridon, P., & Savettieri, G. (2009). Diabetes preceding Parkinson's disease onset. A case-control study. Parkinsonism & Related Disorders, 15(9), 660-4. https://doi.org/10.1016/j.parkreldis.2009.02.013
D'Amelio M, et al. Diabetes Preceding Parkinson's Disease Onset. a Case-control Study. Parkinsonism Relat Disord. 2009;15(9):660-4. PubMed PMID: 19356970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes preceding Parkinson's disease onset. A case-control study. AU - D'Amelio,Marco, AU - Ragonese,Paolo, AU - Callari,Graziella, AU - Di Benedetto,Norma, AU - Palmeri,Barbara, AU - Terruso,Valeria, AU - Salemi,Giuseppe, AU - Famoso,Giorgia, AU - Aridon,Paolo, AU - Savettieri,Giovanni, Y1 - 2009/04/07/ PY - 2008/07/01/received PY - 2009/02/23/revised PY - 2009/02/27/accepted PY - 2009/4/10/entrez PY - 2009/4/10/pubmed PY - 2010/1/9/medline SP - 660 EP - 4 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 15 IS - 9 N2 - OBJECTIVE: To assess the association between diabetes preceding Parkinson's disease (PD) and PD. METHODS: PD individuals were matched to PD free individuals randomly selected from people in the same municipality as the cases. Occurrence of diabetes preceding PD onset among cases and controls was assessed through a structured questionnaire. Information regarding current and past medical treatment and other variables was also collected. We used univariate and multivariate logistic models to calculate crude and adjusted odds ratios (OR). Covariates are adjusted for included education, smoking habit, alcohol and coffee consumption. RESULTS: 318 PD individuals (165 women, 153 men) and 318 matched controls were included in the study. PD patients had a mean age at interview of 66.7 years. Mean age at PD onset was 60.8 years and mean PD duration 5.9 years. We found an inverse association between PD and diabetes preceding PD onset in all groups stratified by gender, age at PD onset, body mass index (BMI), smoking habit, alcohol and coffee consumption. Multivariate analysis yielded the same findings after controlling for the variables (adjusted OR 0.4; 95% CI, 0.2-0.8). CONCLUSIONS: Our findings provide additional support for a potential link between diabetes and PD. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/19356970/Diabetes_preceding_Parkinson's_disease_onset__A_case_control_study_ DB - PRIME DP - Unbound Medicine ER -