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Management of calcium and phosphorus metabolism in hemodialysis patients in Tehran Province, Iran.
Iran J Kidney Dis. 2007 Jul; 1(1):25-8.IJ

Abstract

INTRODUCTION

Our aim was to evaluate the degree of achievement of the recommended values in National Kidney Foundation Dialysis Outcomes Quality Initiative (K/DOQI) guidelines for the laboratory indicators of bone metabolism in patients undergoing hemodialysis (HD) in Tehran province.

MATERIALS AND METHODS

We evaluated the laboratory information of 2630 HD patients in Tehran province. Demographic data of the patients and the clinical information including the duration of dialysis session, dialysate calcium concentration, Kt/V, and serum values of calcium, phosphorus, and intact parathyroid hormone (PTH) were recorded. The laboratory values were compared to the recommended ranges by the K/DOQI work group in patients with end-stage renal disease.

RESULTS

Only 1.8% of the patients could enjoy a successful management according to the K/DOQI recommendations for the 4 target laboratory tests of serum calcium, phosphorus, intact parathyroid hormone, and calcium-phosphorus product. Hypocalcemia was diagnosed in 33.2% of the patients, whereas 13.6% were diagnosed with hypercalcemia. Hypophosphatemia and secondary hyperparathyroidism were diagnosed in 6.8% and 24.2% of the patients, respectively.

CONCLUSIONS

Our findings proved that complying with the recommendations established by the K/DOQI work group in the clinical management of mineral metabolism is very demanding. Phosphate binders frequently lead to untoward toxicities and imbalance in bone metabolism of patients on HD, warranting new cost-effective therapies with fewer side effects. It would be of great interest to analyze, in the future, the benefits derived from the effect of new therapies such as calcimimetics or new phosphate binders regarding the achievement of the K/DOQI guidelines.

Authors+Show Affiliations

Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran. mmahdavi@tums.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19357440

Citation

Mahdavi-Mazdeh, Mitra, et al. "Management of Calcium and Phosphorus Metabolism in Hemodialysis Patients in Tehran Province, Iran." Iranian Journal of Kidney Diseases, vol. 1, no. 1, 2007, pp. 25-8.
Mahdavi-Mazdeh M, Zamyadi M, Norouzi S, et al. Management of calcium and phosphorus metabolism in hemodialysis patients in Tehran Province, Iran. Iran J Kidney Dis. 2007;1(1):25-8.
Mahdavi-Mazdeh, M., Zamyadi, M., Norouzi, S., & Heidary Rouchi, A. (2007). Management of calcium and phosphorus metabolism in hemodialysis patients in Tehran Province, Iran. Iranian Journal of Kidney Diseases, 1(1), 25-8.
Mahdavi-Mazdeh M, et al. Management of Calcium and Phosphorus Metabolism in Hemodialysis Patients in Tehran Province, Iran. Iran J Kidney Dis. 2007;1(1):25-8. PubMed PMID: 19357440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of calcium and phosphorus metabolism in hemodialysis patients in Tehran Province, Iran. AU - Mahdavi-Mazdeh,Mitra, AU - Zamyadi,Mahnaz, AU - Norouzi,Shahram, AU - Heidary Rouchi,Alireza, PY - 2009/4/10/entrez PY - 2007/7/1/pubmed PY - 2009/5/9/medline SP - 25 EP - 8 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 1 IS - 1 N2 - INTRODUCTION: Our aim was to evaluate the degree of achievement of the recommended values in National Kidney Foundation Dialysis Outcomes Quality Initiative (K/DOQI) guidelines for the laboratory indicators of bone metabolism in patients undergoing hemodialysis (HD) in Tehran province. MATERIALS AND METHODS: We evaluated the laboratory information of 2630 HD patients in Tehran province. Demographic data of the patients and the clinical information including the duration of dialysis session, dialysate calcium concentration, Kt/V, and serum values of calcium, phosphorus, and intact parathyroid hormone (PTH) were recorded. The laboratory values were compared to the recommended ranges by the K/DOQI work group in patients with end-stage renal disease. RESULTS: Only 1.8% of the patients could enjoy a successful management according to the K/DOQI recommendations for the 4 target laboratory tests of serum calcium, phosphorus, intact parathyroid hormone, and calcium-phosphorus product. Hypocalcemia was diagnosed in 33.2% of the patients, whereas 13.6% were diagnosed with hypercalcemia. Hypophosphatemia and secondary hyperparathyroidism were diagnosed in 6.8% and 24.2% of the patients, respectively. CONCLUSIONS: Our findings proved that complying with the recommendations established by the K/DOQI work group in the clinical management of mineral metabolism is very demanding. Phosphate binders frequently lead to untoward toxicities and imbalance in bone metabolism of patients on HD, warranting new cost-effective therapies with fewer side effects. It would be of great interest to analyze, in the future, the benefits derived from the effect of new therapies such as calcimimetics or new phosphate binders regarding the achievement of the K/DOQI guidelines. SN - 1735-8582 UR - https://www.unboundmedicine.com/medline/citation/19357440/Management_of_calcium_and_phosphorus_metabolism_in_hemodialysis_patients_in_Tehran_Province_Iran_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/39/38 DB - PRIME DP - Unbound Medicine ER -