Abstract
BACKGROUND
Obesity is an independent predictor for the development and progression of chronic kidney disease (CKD). The effect of weight reduction on the progression of kidney disease in patients with pre-existing CKD is unclear.
METHODS
We conducted a retrospective study at a U.S. university hospital of patients with stage 3 CKD (glomerular filtration rate [GFR] 30-59 mL/min/1.73 m(2)) who had undergone bariatric surgery. The renal function of the included patients was recorded for a 2-year period after surgery to analyze the rate of loss or improvement in renal function. The estimated GFR was calculated using the Modification of Diet in Renal Disease 4-variable formula. Patients who developed acute renal failure in the postoperative period were excluded.
RESULTS
A total of 25 patients with stage 3 CKD were included. Their average body mass index at surgery was 49.8 kg/m(2), the mean GFR was 47.9 mL/min/1.73 m(2), and the mean serum creatinine was 1.4 mg/dL. The body mass index had decreased to 38.4 kg/m(2) (paired t test, P < .001) at the end of 6 months and to 34.5 kg/m(2) (P < .001) at the end of 12 months. The mean systolic blood pressure had decreased from 133 +/- 13 to 128 +/- 17 mm Hg at the end of 12 months. The mean GFR at 6 months of follow-up had improved to 56.6 mL/min/1.73 m(2) (P < .001) and to 61.6 mL/min/1.73 m(2) (P < .001) at 12 months.
CONCLUSION
The renal function of patients with CKD might improve after bariatric surgery. Larger and long-term studies are warranted to further analyze the effect of bariatric surgery on proteinuria and hard end-points such as the development of end-stage renal disease.
TY - JOUR
T1 - Bariatric surgery and progression of chronic kidney disease.
AU - Navaneethan,Sankar D,
AU - Yehnert,Hans,
Y1 - 2009/01/28/
PY - 2009/01/06/received
PY - 2009/01/11/revised
PY - 2009/01/12/accepted
PY - 2009/4/11/entrez
PY - 2009/4/11/pubmed
PY - 2010/3/5/medline
SP - 662
EP - 5
JF - Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
JO - Surg Obes Relat Dis
VL - 5
IS - 6
N2 - BACKGROUND: Obesity is an independent predictor for the development and progression of chronic kidney disease (CKD). The effect of weight reduction on the progression of kidney disease in patients with pre-existing CKD is unclear. METHODS: We conducted a retrospective study at a U.S. university hospital of patients with stage 3 CKD (glomerular filtration rate [GFR] 30-59 mL/min/1.73 m(2)) who had undergone bariatric surgery. The renal function of the included patients was recorded for a 2-year period after surgery to analyze the rate of loss or improvement in renal function. The estimated GFR was calculated using the Modification of Diet in Renal Disease 4-variable formula. Patients who developed acute renal failure in the postoperative period were excluded. RESULTS: A total of 25 patients with stage 3 CKD were included. Their average body mass index at surgery was 49.8 kg/m(2), the mean GFR was 47.9 mL/min/1.73 m(2), and the mean serum creatinine was 1.4 mg/dL. The body mass index had decreased to 38.4 kg/m(2) (paired t test, P < .001) at the end of 6 months and to 34.5 kg/m(2) (P < .001) at the end of 12 months. The mean systolic blood pressure had decreased from 133 +/- 13 to 128 +/- 17 mm Hg at the end of 12 months. The mean GFR at 6 months of follow-up had improved to 56.6 mL/min/1.73 m(2) (P < .001) and to 61.6 mL/min/1.73 m(2) (P < .001) at 12 months. CONCLUSION: The renal function of patients with CKD might improve after bariatric surgery. Larger and long-term studies are warranted to further analyze the effect of bariatric surgery on proteinuria and hard end-points such as the development of end-stage renal disease.
SN - 1878-7533
UR - https://www.unboundmedicine.com/medline/citation/19359221/Bariatric_surgery_and_progression_of_chronic_kidney_disease_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1550-7289(09)00058-6
DB - PRIME
DP - Unbound Medicine
ER -
