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Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa.
Pediatr Pulmonol 2009; 44(5):464-71PP

Abstract

BACKGROUND AND AIMS

Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients.

METHODS

Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa. Each parameter was measured every 15 days during 3-6 months.

RESULTS

Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV(1) (P < 0.05).

CONCLUSION

In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT.

Authors+Show Affiliations

EA 3925, Université Lille 2 Droit et Santé & Division of Gastroenterology, Hepatology and Nutrition, Cystic Fibrosis Center, Lille, France. l-beghin@chru-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19360849

Citation

Béghin, Laurent, et al. "Changes in Lung Function in Young Cystic Fibrosis Patients Between Two Courses of Intravenous Antibiotics Against Pseudomonas Aeruginosa." Pediatric Pulmonology, vol. 44, no. 5, 2009, pp. 464-71.
Béghin L, Michaud L, Loeuille GA, et al. Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa. Pediatr Pulmonol. 2009;44(5):464-71.
Béghin, L., Michaud, L., Loeuille, G. A., Wizla-Derambure, N., Sayah, H., Sardet, A., ... Gottrand, F. (2009). Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa. Pediatric Pulmonology, 44(5), pp. 464-71. doi:10.1002/ppul.21017.
Béghin L, et al. Changes in Lung Function in Young Cystic Fibrosis Patients Between Two Courses of Intravenous Antibiotics Against Pseudomonas Aeruginosa. Pediatr Pulmonol. 2009;44(5):464-71. PubMed PMID: 19360849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in lung function in young cystic fibrosis patients between two courses of intravenous antibiotics against Pseudomonas aeruginosa. AU - Béghin,Laurent, AU - Michaud,Laurent, AU - Loeuille,Guy-André, AU - Wizla-Derambure,Nathalie, AU - Sayah,Hocine, AU - Sardet,Anne, AU - Thumerelle,Caroline, AU - Deschildre,Antoine, AU - Turck,Dominique, AU - Gottrand,Frédéric, PY - 2009/4/11/entrez PY - 2009/4/11/pubmed PY - 2009/8/4/medline SP - 464 EP - 71 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 44 IS - 5 N2 - BACKGROUND AND AIMS: Repeated intravenous antibiotic therapy (IVAT) against chronic pulmonary infection with Pseudomonas aeruginosa is often necessary in cystic fibrosis patients (CF). The aim of this study was to monitor kinetics of degradation of pulmonary and nutritional status after IVAT in CF patients. METHODS: Lung function, nutritional status and physical activity (PA) were measured for 21 CF patients (mean +/- SD age, 16 +/- 1.9 years; 9 boys) who were chronically colonized by P. aeruginosa. Each parameter was measured every 15 days during 3-6 months. RESULTS: Nutritional status as well as PA did not change in the interval of 2 IVAT. In contrary, lung function worsened with a decrease of -14.6% of the FEV(1) (P < 0.05). CONCLUSION: In CF, there is a progressive decrease in lung function without any evident deterioration of nutritional status and PA between two IVAT. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/19360849/Changes_in_lung_function_in_young_cystic_fibrosis_patients_between_two_courses_of_intravenous_antibiotics_against_Pseudomonas_aeruginosa_ L2 - https://doi.org/10.1002/ppul.21017 DB - PRIME DP - Unbound Medicine ER -