Citation
Cipolletta, L, et al. "Acrylate Glue Injection for Acutely Bleeding Oesophageal Varices: a Prospective Cohort Study." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 41, no. 10, 2009, pp. 729-34.
Cipolletta L, Zambelli A, Bianco MA, et al. Acrylate glue injection for acutely bleeding oesophageal varices: A prospective cohort study. Dig Liver Dis. 2009;41(10):729-34.
Cipolletta, L., Zambelli, A., Bianco, M. A., De Grazia, F., Meucci, C., Lupinacci, G., Salerno, R., Piscopo, R., Marmo, R., Orsini, L., & Rotondano, G. (2009). Acrylate glue injection for acutely bleeding oesophageal varices: A prospective cohort study. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 41(10), 729-34. https://doi.org/10.1016/j.dld.2009.02.006
Cipolletta L, et al. Acrylate Glue Injection for Acutely Bleeding Oesophageal Varices: a Prospective Cohort Study. Dig Liver Dis. 2009;41(10):729-34. PubMed PMID: 19362522.
TY - JOUR
T1 - Acrylate glue injection for acutely bleeding oesophageal varices: A prospective cohort study.
AU - Cipolletta,L,
AU - Zambelli,A,
AU - Bianco,M A,
AU - De Grazia,F,
AU - Meucci,C,
AU - Lupinacci,G,
AU - Salerno,R,
AU - Piscopo,R,
AU - Marmo,R,
AU - Orsini,L,
AU - Rotondano,G,
Y1 - 2009/04/11/
PY - 2008/11/14/received
PY - 2008/12/14/revised
PY - 2009/02/10/accepted
PY - 2009/4/14/entrez
PY - 2009/4/14/pubmed
PY - 2009/12/16/medline
SP - 729
EP - 34
JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
JO - Dig Liver Dis
VL - 41
IS - 10
N2 - BACKGROUND: Acrylate glue injection is seldom performed in patients with bleeding oesophageal varices. AIM: To assess efficacy and safety of acrylate glue injection in patients with bleeding oesophageal varices, as well as the impact of this technique on subsequent variceal ligation. METHODS: Prospective study on 133 consecutive cirrhotic patients treated by intravariceal injection of undiluted N-butyl-2-cyanoacrylate into the bleeding varix. Outcome measures were initial haemostasis, recurrent bleeding, complications and mortality at 6 weeks. RESULTS: 52 patients were actively bleeding at endoscopy and 81 showed stigmata of recent haemorrhage. Initial haemostasis was achieved in 49/52 active bleeders (94.2% [95% CI 85.1-98.5]). Overall, early recurrent bleeding occurred in 7 patients (5.2% [95% CI 2.3-10.1]). No major procedure-related complication was recorded. At 6 weeks, death occurred in 11 patients, with an overall bleeding-related mortality of 8.2% [95% CI 5.8-15.3]. Mortality was higher in active (15.4% [95% CI 6.9-28.1]) than non-active bleeders (3.7% [95% CI 0.8-10.4], OR 4.7 [95% CI 1.05-28.7], p=0.02). Of those surviving the first bleeding episode, 112 patients subsequently underwent ligation. No technical difficulties were encountered in performing the banding procedure which was successfully completed in all cases. CONCLUSIONS: Emergency injection of acrylate glue is safe and effective for the treatment of acute bleeding oesophageal varices and does not hamper subsequent variceal ligation.
SN - 1878-3562
UR - https://www.unboundmedicine.com/medline/citation/19362522/Acrylate_glue_injection_for_acutely_bleeding_oesophageal_varices:_A_prospective_cohort_study_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(09)00050-4
DB - PRIME
DP - Unbound Medicine
ER -