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Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study.
Eur Rev Med Pharmacol Sci. 2009 Jan-Feb; 13(1):51-5.ER

Abstract

BACKGROUND AND OBJECTIVES

Epidemiological and interventional studies suggest that a high dietary intake of n-3 polyunsaturated fatty acids may confer a protective effect against atherosclerotic disease and reduce serum triglycerides levels. The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia.

SUBJECTS

A total of 30 patients (16 males and 14 females) with diabetes mellitus type 2 and hypertriglyceridemia (> 200 mg/dl) were included in the study. Patients received two capsules of eicosapentaenoic 465 mg and docosahexanoic 375 mg daily for 12 weeks.

RESULTS

Triglycerides levels and non HDL-cholesterol decreased (326 +/- 113.5 vs. 216.4 +/- 57 mg/dl; p < 0.05) and (103.87 +/- 44 vs. 89.6 +/- 14 mg/dl; p < 0.05), respectively. HDL-cholesterol levels increased (39.6 +/- 10.7 vs. 46.4 +/- 8.7 mg/dl; p < 0.05). C reactive protein decreased (5.98 +/- 3.9 vs. 3.9 +/- 1.6 mg/dl; p < 0.05) and TNF-alpha levels decreased (16.24 +/- 5.5 vs. 13.3 +/- 5.8 pg/dl; p < 0.05), without significant changes in IL-6 levels. In conclusion, an n-3 polyunsaturated intervention improved lipid profile and inflammatory markers in patients with diabetes mellitus type 2 and hypertriglyceridaemia.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

19364085

Citation

De Luis, D A., et al. "Effect of Omega-3 Fatty Acids On Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus and Hypertriglyceridemia: an Open Study." European Review for Medical and Pharmacological Sciences, vol. 13, no. 1, 2009, pp. 51-5.
De Luis DA, Conde R, Aller R, et al. Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study. Eur Rev Med Pharmacol Sci. 2009;13(1):51-5.
De Luis, D. A., Conde, R., Aller, R., Izaola, O., González Sagrado, M., Perez Castrillón, J. L., Dueñas, A., & Romero, E. (2009). Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study. European Review for Medical and Pharmacological Sciences, 13(1), 51-5.
De Luis DA, et al. Effect of Omega-3 Fatty Acids On Cardiovascular Risk Factors in Patients With Type 2 Diabetes Mellitus and Hypertriglyceridemia: an Open Study. Eur Rev Med Pharmacol Sci. 2009;13(1):51-5. PubMed PMID: 19364085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omega-3 fatty acids on cardiovascular risk factors in patients with type 2 diabetes mellitus and hypertriglyceridemia: an open study. AU - De Luis,D A, AU - Conde,R, AU - Aller,R, AU - Izaola,O, AU - González Sagrado,M, AU - Perez Castrillón,J L, AU - Dueñas,A, AU - Romero,E, PY - 2009/4/15/entrez PY - 2009/4/15/pubmed PY - 2009/5/13/medline SP - 51 EP - 5 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 13 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Epidemiological and interventional studies suggest that a high dietary intake of n-3 polyunsaturated fatty acids may confer a protective effect against atherosclerotic disease and reduce serum triglycerides levels. The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia. SUBJECTS: A total of 30 patients (16 males and 14 females) with diabetes mellitus type 2 and hypertriglyceridemia (> 200 mg/dl) were included in the study. Patients received two capsules of eicosapentaenoic 465 mg and docosahexanoic 375 mg daily for 12 weeks. RESULTS: Triglycerides levels and non HDL-cholesterol decreased (326 +/- 113.5 vs. 216.4 +/- 57 mg/dl; p < 0.05) and (103.87 +/- 44 vs. 89.6 +/- 14 mg/dl; p < 0.05), respectively. HDL-cholesterol levels increased (39.6 +/- 10.7 vs. 46.4 +/- 8.7 mg/dl; p < 0.05). C reactive protein decreased (5.98 +/- 3.9 vs. 3.9 +/- 1.6 mg/dl; p < 0.05) and TNF-alpha levels decreased (16.24 +/- 5.5 vs. 13.3 +/- 5.8 pg/dl; p < 0.05), without significant changes in IL-6 levels. In conclusion, an n-3 polyunsaturated intervention improved lipid profile and inflammatory markers in patients with diabetes mellitus type 2 and hypertriglyceridaemia. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/19364085/Effect_of_omega_3_fatty_acids_on_cardiovascular_risk_factors_in_patients_with_type_2_diabetes_mellitus_and_hypertriglyceridemia:_an_open_study_ L2 - http://www.diseaseinfosearch.org/result/8215 DB - PRIME DP - Unbound Medicine ER -