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The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3(IV)NC1 is associated with disease severity.
Hum Immunol. 2009 Jun; 70(6):425-9.HI

Abstract

The current study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha3 chain [rHalpha3(IV)NC1]. Anti-GBM IgG1 could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 in groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the major subclasses with detectable IgG1; in group C, IgG1 became predominant and IgG3 was detectable; in group D, four IgG subclasses could be detected. In conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG1 and IgG3 may play a major role in the initiation and progression of the disease.

Authors+Show Affiliations

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19364515

Citation

Zhao, Juan, et al. "The Immunoglobulin G Subclass Distribution of anti-GBM Autoantibodies Against rHalpha3(IV)NC1 Is Associated With Disease Severity." Human Immunology, vol. 70, no. 6, 2009, pp. 425-9.
Zhao J, Yan Y, Cui Z, et al. The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3(IV)NC1 is associated with disease severity. Hum Immunol. 2009;70(6):425-9.
Zhao, J., Yan, Y., Cui, Z., Yang, R., & Zhao, M. H. (2009). The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3(IV)NC1 is associated with disease severity. Human Immunology, 70(6), 425-9. https://doi.org/10.1016/j.humimm.2009.04.004
Zhao J, et al. The Immunoglobulin G Subclass Distribution of anti-GBM Autoantibodies Against rHalpha3(IV)NC1 Is Associated With Disease Severity. Hum Immunol. 2009;70(6):425-9. PubMed PMID: 19364515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immunoglobulin G subclass distribution of anti-GBM autoantibodies against rHalpha3(IV)NC1 is associated with disease severity. AU - Zhao,Juan, AU - Yan,Yu, AU - Cui,Zhao, AU - Yang,Rui, AU - Zhao,Ming-Hui, Y1 - 2009/04/11/ PY - 2009/01/01/received PY - 2009/03/27/revised PY - 2009/04/06/accepted PY - 2009/4/15/entrez PY - 2009/4/15/pubmed PY - 2009/8/20/medline SP - 425 EP - 9 JF - Human immunology JO - Hum Immunol VL - 70 IS - 6 N2 - The current study aimed to investigate the association between antiglomerular basement membrane (GBM) immunoglobulin (Ig) G subclass distribution and the severity of anti-GBM nephritis in human beings. Natural anti-GBM IgG affinity purified from five healthy donors was defined as group A. A total of 73 Chinese patients with anti-GBM disease were divided into three groups (groups B, C, and D) according to their serum creatinine (Scr) on diagnosis. Anti-GBM IgG subclasses were detected by enzyme-linked immunosorbent assay using recombinant human noncollagenous domain 1 of type IV collagen of the alpha3 chain [rHalpha3(IV)NC1]. Anti-GBM IgG1 could not be detected in group A (0%), appeared in group B (7.7%), was significantly higher in group C (69%), and was the highest in group D (93.5%). The frequency of IgG3 in groups C and D was significantly higher than that in groups A and B. In group A, anti-GBM IgG subclass distribution was restricted to IgG4 and IgG2; in group B, IgG2 and IgG4 remained the major subclasses with detectable IgG1; in group C, IgG1 became predominant and IgG3 was detectable; in group D, four IgG subclasses could be detected. In conclusion, anti-GBM autoantibody IgG subclass distribution was associated with disease severity. IgG1 and IgG3 may play a major role in the initiation and progression of the disease. SN - 1879-1166 UR - https://www.unboundmedicine.com/medline/citation/19364515/The_immunoglobulin_G_subclass_distribution_of_anti_GBM_autoantibodies_against_rHalpha3_IV_NC1_is_associated_with_disease_severity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(09)00092-5 DB - PRIME DP - Unbound Medicine ER -