Tags

Type your tag names separated by a space and hit enter

Basic neuroanatomy and neuropharmacology of cannabinoids.

Abstract

Humans have used Cannabis sativa (marijuana) for at least 12,000 years, but researchers have only recently described an endogenous cannabinoid system. The endocannabinoid system modulates an array of physiological and psychological functions. Endocannabinoids are widely distributed throughout the body, including the central nervous system (CNS). This article gives a basic overview of endocannabinoid neuroanatomy and function. Several endocannabinoids have been discovered to date, and their roles are being elucidated. Two G-protein coupled cannabinoid receptors, CB1R and CB2R, have been identified, although other candidate receptors exist, including ion channel and nuclear receptors that might be components of the endocannabinoid system. It appears that cannabinoids are dysregulated in a number of psychiatric disorders and might be involved in their pathogenesis. There is now evidence that manipulation of the endocannabinoid system could be a therapeutic target for a variety of conditions.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pharmaceutical Sciences, Campbell University School of Pharmacy, Buies Creek, North Carolina 27506, USA. breivogel@campbell.edu

    Source

    MeSH

    Animals
    Brain
    Cannabinoid Receptor Agonists
    Cannabinoid Receptor Modulators
    Cannabinoids
    Humans
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    19367505

    Citation

    Breivogel, Chris S., and Laura J. Sim-Selley. "Basic Neuroanatomy and Neuropharmacology of Cannabinoids." International Review of Psychiatry (Abingdon, England), vol. 21, no. 2, 2009, pp. 113-21.
    Breivogel CS, Sim-Selley LJ. Basic neuroanatomy and neuropharmacology of cannabinoids. Int Rev Psychiatry. 2009;21(2):113-21.
    Breivogel, C. S., & Sim-Selley, L. J. (2009). Basic neuroanatomy and neuropharmacology of cannabinoids. International Review of Psychiatry (Abingdon, England), 21(2), pp. 113-21. doi:10.1080/09540260902782760.
    Breivogel CS, Sim-Selley LJ. Basic Neuroanatomy and Neuropharmacology of Cannabinoids. Int Rev Psychiatry. 2009;21(2):113-21. PubMed PMID: 19367505.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Basic neuroanatomy and neuropharmacology of cannabinoids. AU - Breivogel,Chris S, AU - Sim-Selley,Laura J, PY - 2009/4/16/entrez PY - 2009/4/16/pubmed PY - 2009/8/6/medline SP - 113 EP - 21 JF - International review of psychiatry (Abingdon, England) JO - Int Rev Psychiatry VL - 21 IS - 2 N2 - Humans have used Cannabis sativa (marijuana) for at least 12,000 years, but researchers have only recently described an endogenous cannabinoid system. The endocannabinoid system modulates an array of physiological and psychological functions. Endocannabinoids are widely distributed throughout the body, including the central nervous system (CNS). This article gives a basic overview of endocannabinoid neuroanatomy and function. Several endocannabinoids have been discovered to date, and their roles are being elucidated. Two G-protein coupled cannabinoid receptors, CB1R and CB2R, have been identified, although other candidate receptors exist, including ion channel and nuclear receptors that might be components of the endocannabinoid system. It appears that cannabinoids are dysregulated in a number of psychiatric disorders and might be involved in their pathogenesis. There is now evidence that manipulation of the endocannabinoid system could be a therapeutic target for a variety of conditions. SN - 1369-1627 UR - https://www.unboundmedicine.com/medline/citation/19367505/Basic_neuroanatomy_and_neuropharmacology_of_cannabinoids_ L2 - http://www.tandfonline.com/doi/full/10.1080/09540260902782760 DB - PRIME DP - Unbound Medicine ER -