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Basic neuroanatomy and neuropharmacology of cannabinoids.
Int Rev Psychiatry 2009; 21(2):113-21IR

Abstract

Humans have used Cannabis sativa (marijuana) for at least 12,000 years, but researchers have only recently described an endogenous cannabinoid system. The endocannabinoid system modulates an array of physiological and psychological functions. Endocannabinoids are widely distributed throughout the body, including the central nervous system (CNS). This article gives a basic overview of endocannabinoid neuroanatomy and function. Several endocannabinoids have been discovered to date, and their roles are being elucidated. Two G-protein coupled cannabinoid receptors, CB1R and CB2R, have been identified, although other candidate receptors exist, including ion channel and nuclear receptors that might be components of the endocannabinoid system. It appears that cannabinoids are dysregulated in a number of psychiatric disorders and might be involved in their pathogenesis. There is now evidence that manipulation of the endocannabinoid system could be a therapeutic target for a variety of conditions.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Campbell University School of Pharmacy, Buies Creek, North Carolina 27506, USA. breivogel@campbell.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19367505

Citation

Breivogel, Chris S., and Laura J. Sim-Selley. "Basic Neuroanatomy and Neuropharmacology of Cannabinoids." International Review of Psychiatry (Abingdon, England), vol. 21, no. 2, 2009, pp. 113-21.
Breivogel CS, Sim-Selley LJ. Basic neuroanatomy and neuropharmacology of cannabinoids. Int Rev Psychiatry. 2009;21(2):113-21.
Breivogel, C. S., & Sim-Selley, L. J. (2009). Basic neuroanatomy and neuropharmacology of cannabinoids. International Review of Psychiatry (Abingdon, England), 21(2), pp. 113-21. doi:10.1080/09540260902782760.
Breivogel CS, Sim-Selley LJ. Basic Neuroanatomy and Neuropharmacology of Cannabinoids. Int Rev Psychiatry. 2009;21(2):113-21. PubMed PMID: 19367505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Basic neuroanatomy and neuropharmacology of cannabinoids. AU - Breivogel,Chris S, AU - Sim-Selley,Laura J, PY - 2009/4/16/entrez PY - 2009/4/16/pubmed PY - 2009/8/6/medline SP - 113 EP - 21 JF - International review of psychiatry (Abingdon, England) JO - Int Rev Psychiatry VL - 21 IS - 2 N2 - Humans have used Cannabis sativa (marijuana) for at least 12,000 years, but researchers have only recently described an endogenous cannabinoid system. The endocannabinoid system modulates an array of physiological and psychological functions. Endocannabinoids are widely distributed throughout the body, including the central nervous system (CNS). This article gives a basic overview of endocannabinoid neuroanatomy and function. Several endocannabinoids have been discovered to date, and their roles are being elucidated. Two G-protein coupled cannabinoid receptors, CB1R and CB2R, have been identified, although other candidate receptors exist, including ion channel and nuclear receptors that might be components of the endocannabinoid system. It appears that cannabinoids are dysregulated in a number of psychiatric disorders and might be involved in their pathogenesis. There is now evidence that manipulation of the endocannabinoid system could be a therapeutic target for a variety of conditions. SN - 1369-1627 UR - https://www.unboundmedicine.com/medline/citation/19367505/Basic_neuroanatomy_and_neuropharmacology_of_cannabinoids_ L2 - http://www.tandfonline.com/doi/full/10.1080/09540260902782760 DB - PRIME DP - Unbound Medicine ER -