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Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
Brain Res. 2009 Apr 06; 1264:57-66.BR

Abstract

The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articular injection of Complete Freund's Adjuvant (CFA). The paw withdrawal latency (PWL) from a thermal stimulus was measured in awake rats. Intraperitoneal (i.p.) injection of dexmedetomidine (2.5, 5, 10 and 20 microg/kg) or gabapentin (25, 50, 100 and 200 mg/kg) significantly and dose-dependently increased the PWL of the hindpaw ipsilateral to CFA-injected joint. The PWLs of the non-injected and normal saline (NS)-injected hindpaws were not significantly affected by the two agents at the most doses tested except the highest dose of dexmedetomidine (20 microg/kg). Although low dose of dexmedetomidine (2.5 microg/kg) or gabapentin (25 mg/kg) alone did not affect or lightly increased PWLs of the hindpaw ipsilateral to CFA-injected joint, a combination of dexmedetomidine and gabapentin (2.5 microg/kg+25 mg/kg, or 5 microg/kg+50 mg/kg) significantly reversed CFA-induced thermal hyperalgesia for 60 min without sedation/motor impairment. These results provide the first identification that co-application of dexmedetomidine and gabapentin may synergistically antagonize inflammatory pain, and this might prove to be beneficial in the treatment of arthritic pain.

Authors+Show Affiliations

Department of Anesthesiology, Changhai Hospital, The Second Military Medical University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19368840

Citation

Zhang, Wei-Shi, et al. "Antihyperalgesic Effect of Systemic Dexmedetomidine and Gabapentin in a Rat Model of Monoarthritis." Brain Research, vol. 1264, 2009, pp. 57-66.
Zhang WS, Xu H, Xu B, et al. Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. Brain Res. 2009;1264:57-66.
Zhang, W. S., Xu, H., Xu, B., Sun, S., Deng, X. M., & Zhang, Y. Q. (2009). Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. Brain Research, 1264, 57-66. https://doi.org/10.1016/j.brainres.2009.01.029
Zhang WS, et al. Antihyperalgesic Effect of Systemic Dexmedetomidine and Gabapentin in a Rat Model of Monoarthritis. Brain Res. 2009 Apr 6;1264:57-66. PubMed PMID: 19368840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. AU - Zhang,Wei-Shi, AU - Xu,Hua, AU - Xu,Bo, AU - Sun,Shan, AU - Deng,Xiao-Ming, AU - Zhang,Yu-Qiu, Y1 - 2009/01/29/ PY - 2008/11/07/received PY - 2009/01/19/revised PY - 2009/01/20/accepted PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2009/11/18/medline SP - 57 EP - 66 JF - Brain research JO - Brain Res VL - 1264 N2 - The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation. Monoarthritis of rat ankle joint was induced by an intra-articular injection of Complete Freund's Adjuvant (CFA). The paw withdrawal latency (PWL) from a thermal stimulus was measured in awake rats. Intraperitoneal (i.p.) injection of dexmedetomidine (2.5, 5, 10 and 20 microg/kg) or gabapentin (25, 50, 100 and 200 mg/kg) significantly and dose-dependently increased the PWL of the hindpaw ipsilateral to CFA-injected joint. The PWLs of the non-injected and normal saline (NS)-injected hindpaws were not significantly affected by the two agents at the most doses tested except the highest dose of dexmedetomidine (20 microg/kg). Although low dose of dexmedetomidine (2.5 microg/kg) or gabapentin (25 mg/kg) alone did not affect or lightly increased PWLs of the hindpaw ipsilateral to CFA-injected joint, a combination of dexmedetomidine and gabapentin (2.5 microg/kg+25 mg/kg, or 5 microg/kg+50 mg/kg) significantly reversed CFA-induced thermal hyperalgesia for 60 min without sedation/motor impairment. These results provide the first identification that co-application of dexmedetomidine and gabapentin may synergistically antagonize inflammatory pain, and this might prove to be beneficial in the treatment of arthritic pain. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/19368840/Antihyperalgesic_effect_of_systemic_dexmedetomidine_and_gabapentin_in_a_rat_model_of_monoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(09)00172-3 DB - PRIME DP - Unbound Medicine ER -