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Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?
Fertil Steril. 2010 Jun; 94(1):205-10.FS

Abstract

OBJECTIVE

To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS).

DESIGN

Prospective study.

SETTING

Reproductive Center of Peking University Third Hospital.

PATIENT(S)

Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals.

INTERVENTION(S)

Fasting serum samples.

MAIN OUTCOME MEASURE(S)

Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR).

RESULT(S)

We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycometabolism and lipid metabolism, but its role in PCOS has been unknown. The serum levels of apoC-I in the patients with PCOS were statistically significantly elevated compared with those of controls, especially in women with insulin resistance. The lean PCOS women had higher apoC-I levels than controls. In patients with PCOS and without any abnormal serum lipid index, apoC-I levels were still higher than in controls. Analysis showed that apoC-I correlated with body mass index, triglycerides, high-density lipoprotein cholesterol, apoA1, and HOMA-IR.

CONCLUSION(S)

ApoC-I may have an important role in glucose and lipid metabolism, and may be useful for early demonstration of metabolic abnormality in women with PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Peking University Third Hospital, Pekin, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19368908

Citation

Huang, Shuo, et al. "Can Serum Apolipoprotein C-I Demonstrate Metabolic Abnormality Early in Women With Polycystic Ovary Syndrome?" Fertility and Sterility, vol. 94, no. 1, 2010, pp. 205-10.
Huang S, Qiao J, Li R, et al. Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome? Fertil Steril. 2010;94(1):205-10.
Huang, S., Qiao, J., Li, R., Wang, L., & Li, M. (2010). Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome? Fertility and Sterility, 94(1), 205-10. https://doi.org/10.1016/j.fertnstert.2009.03.005
Huang S, et al. Can Serum Apolipoprotein C-I Demonstrate Metabolic Abnormality Early in Women With Polycystic Ovary Syndrome. Fertil Steril. 2010;94(1):205-10. PubMed PMID: 19368908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome? AU - Huang,Shuo, AU - Qiao,Jie, AU - Li,Rong, AU - Wang,Lina, AU - Li,Meizhi, Y1 - 2009/04/14/ PY - 2009/01/13/received PY - 2009/02/25/revised PY - 2009/03/02/accepted PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2010/6/18/medline SP - 205 EP - 10 JF - Fertility and sterility JO - Fertil Steril VL - 94 IS - 1 N2 - OBJECTIVE: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: Reproductive Center of Peking University Third Hospital. PATIENT(S): Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals. INTERVENTION(S): Fasting serum samples. MAIN OUTCOME MEASURE(S): Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR). RESULT(S): We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycometabolism and lipid metabolism, but its role in PCOS has been unknown. The serum levels of apoC-I in the patients with PCOS were statistically significantly elevated compared with those of controls, especially in women with insulin resistance. The lean PCOS women had higher apoC-I levels than controls. In patients with PCOS and without any abnormal serum lipid index, apoC-I levels were still higher than in controls. Analysis showed that apoC-I correlated with body mass index, triglycerides, high-density lipoprotein cholesterol, apoA1, and HOMA-IR. CONCLUSION(S): ApoC-I may have an important role in glucose and lipid metabolism, and may be useful for early demonstration of metabolic abnormality in women with PCOS. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/19368908/Can_serum_apolipoprotein_C_I_demonstrate_metabolic_abnormality_early_in_women_with_polycystic_ovary_syndrome L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(09)00524-X DB - PRIME DP - Unbound Medicine ER -