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Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children.
Metabolism. 2009 Jun; 58(6):798-802.M

Abstract

Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined.

Authors+Show Affiliations

Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19368945

Citation

Yun, Kyung Eun, et al. "Association Between Adipocyte Fatty Acid-binding Protein Levels and Childhood Obesity in Korean Children." Metabolism: Clinical and Experimental, vol. 58, no. 6, 2009, pp. 798-802.
Yun KE, Kim SM, Choi KM, et al. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. Metab Clin Exp. 2009;58(6):798-802.
Yun, K. E., Kim, S. M., Choi, K. M., & Park, H. S. (2009). Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. Metabolism: Clinical and Experimental, 58(6), 798-802. https://doi.org/10.1016/j.metabol.2009.01.017
Yun KE, et al. Association Between Adipocyte Fatty Acid-binding Protein Levels and Childhood Obesity in Korean Children. Metab Clin Exp. 2009;58(6):798-802. PubMed PMID: 19368945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. AU - Yun,Kyung Eun, AU - Kim,Seon Mee, AU - Choi,Kyung Mook, AU - Park,Hye Soon, PY - 2008/10/28/received PY - 2009/01/06/accepted PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2009/6/11/medline SP - 798 EP - 802 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 58 IS - 6 N2 - Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19368945/Association_between_adipocyte_fatty_acid_binding_protein_levels_and_childhood_obesity_in_Korean_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00056-0 DB - PRIME DP - Unbound Medicine ER -