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Increased prevalance of colorectal adenoma in patients with sporadic duodenal adenoma.
Eur J Gastroenterol Hepatol 2009; 21(7):816-8EJ

Abstract

OBJECTIVES

Duodenal adenomas are common in familial adenomatous polyposis (FAP). It is, however, not known whether patients with duodenal adenomas without FAP should undergo routine colonoscopy for detection of colorectal neoplasia. The aim of this study was to evaluate the correlation between the incidence of sporadic duodenal adenomas and colorectal neoplasias.

METHODS

Patients with sporadic duodenal adenomas and without FAP were retrospectively evaluated for the existence of colorectal neoplasia. Each patient was compared with three randomly selected age and sex-matched controls.

RESULTS

Sporadic duodenal adenomas were diagnosed by endoscopy in 51 patients, of whom 48 underwent additional colonoscopy. The mean age of the 48 analysed patients was 66 (40-83) years (women:men=23 : 25). Colorectal neoplasia was significantly more common among patients with duodenal adenomas (75% vs. 27.7%; P<0.05; odds ratio=7.80 [95% confidence interval 3.48-17.72]).

CONCLUSION

In this case control study, the prevalence of colorectal adenomas in patients with sporadic duodenal adenomas without FAP was significantly increased compared with the average population. Therefore, patients with duodenal adenomas should be screened for the occurrence of colorectal adenomas.

Authors+Show Affiliations

Gastroenterologische Praxis im Evang. Krankenhaus Hochstift/Worms, Germany. endo@gastro-praxis.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19369885

Citation

Dariusz, Apel, and Rudi Jochen. "Increased Prevalance of Colorectal Adenoma in Patients With Sporadic Duodenal Adenoma." European Journal of Gastroenterology & Hepatology, vol. 21, no. 7, 2009, pp. 816-8.
Dariusz A, Jochen R. Increased prevalance of colorectal adenoma in patients with sporadic duodenal adenoma. Eur J Gastroenterol Hepatol. 2009;21(7):816-8.
Dariusz, A., & Jochen, R. (2009). Increased prevalance of colorectal adenoma in patients with sporadic duodenal adenoma. European Journal of Gastroenterology & Hepatology, 21(7), pp. 816-8. doi:10.1097/MEG.0b013e328306c7cc.
Dariusz A, Jochen R. Increased Prevalance of Colorectal Adenoma in Patients With Sporadic Duodenal Adenoma. Eur J Gastroenterol Hepatol. 2009;21(7):816-8. PubMed PMID: 19369885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased prevalance of colorectal adenoma in patients with sporadic duodenal adenoma. AU - Dariusz,Apel, AU - Jochen,Rudi, PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2010/7/16/medline SP - 816 EP - 8 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 21 IS - 7 N2 - OBJECTIVES: Duodenal adenomas are common in familial adenomatous polyposis (FAP). It is, however, not known whether patients with duodenal adenomas without FAP should undergo routine colonoscopy for detection of colorectal neoplasia. The aim of this study was to evaluate the correlation between the incidence of sporadic duodenal adenomas and colorectal neoplasias. METHODS: Patients with sporadic duodenal adenomas and without FAP were retrospectively evaluated for the existence of colorectal neoplasia. Each patient was compared with three randomly selected age and sex-matched controls. RESULTS: Sporadic duodenal adenomas were diagnosed by endoscopy in 51 patients, of whom 48 underwent additional colonoscopy. The mean age of the 48 analysed patients was 66 (40-83) years (women:men=23 : 25). Colorectal neoplasia was significantly more common among patients with duodenal adenomas (75% vs. 27.7%; P<0.05; odds ratio=7.80 [95% confidence interval 3.48-17.72]). CONCLUSION: In this case control study, the prevalence of colorectal adenomas in patients with sporadic duodenal adenomas without FAP was significantly increased compared with the average population. Therefore, patients with duodenal adenomas should be screened for the occurrence of colorectal adenomas. SN - 1473-5687 UR - https://www.unboundmedicine.com/medline/citation/19369885/Increased_prevalance_of_colorectal_adenoma_in_patients_with_sporadic_duodenal_adenoma_ L2 - http://dx.doi.org/10.1097/MEG.0b013e328306c7cc DB - PRIME DP - Unbound Medicine ER -