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Association between polymorphisms in tumor necrosis factor (TNF) and TNF receptor genes and circulating TNF, soluble TNF receptor levels, and bone mineral density in postmenopausal Korean women.
Menopause. 2009 Sep-Oct; 16(5):1014-20.M

Abstract

OBJECTIVE

The aim of the present study was to investigate the relationship of polymorphisms in the tumor necrosis factor (TNF)-alpha, TNF-beta, and TNF receptor (TNFR) genes to circulating TNF, soluble TNFR (sTNFR) levels, and bone mineral density (BMD) in women.

METHODS

The TNF-alpha G(-308)A, C(-857)T, C(-863)A, T(-1031)C, TNF-beta A252G, TNFRI A36G, TNFRII T676G, A1663G, A1668G, and C1690T polymorphisms were analyzed in 377 postmenopausal Korean women. The levels of serum TNF-alpha, TNF-beta, sTNFRI, sTNFRII, and bone turnover markers were measured. BMD was examined by dual energy x-ray absorptiometry.

RESULTS

After adjustment for age, body mass index, and years since menopause, no significant differences in BMD of the lumbar spine and femoral neck and serum levels of bone turnover markers were detected, according to single polymorphisms in TNF and TNFR genes and combined polymorphisms. However, the frequencies of the TT genotype of TNF-alpha T(-1031)C polymorphism, the non-AA genotype of TNF-beta A252G polymorphism, and the GG genotype of TNFRII A1663G polymorphism were significantly higher in osteoporotic women than in women with normal BMD, respectively (P < 0.05). The TNFRII T676G polymorphism affected the serum sTNFRI and sTNFRII levels. The serum sTNFRII levels in the CC genotype of TNFRII C1690T polymorphism were the highest, with a G or C allele dose effect, and the TNFRII G676C/C1690T haplotype genotype also affected serum sTNFRII levels.

CONCLUSIONS

TNF-alpha T(-1031)C, TNF-beta A252G, and TNFRII A1663G polymorphisms may be genetic factors for osteoporosis in Korean postmenopausal women, and the TNFRII T676G and C1690T polymorphisms and their combined polymorphism affected serum sTNFRII levels. The TNFRII T676G polymorphism also affected the serum sTNFRI levels.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19369902

Citation

Kim, Hoon, et al. "Association Between Polymorphisms in Tumor Necrosis Factor (TNF) and TNF Receptor Genes and Circulating TNF, Soluble TNF Receptor Levels, and Bone Mineral Density in Postmenopausal Korean Women." Menopause (New York, N.Y.), vol. 16, no. 5, 2009, pp. 1014-20.
Kim H, Chun S, Ku SY, et al. Association between polymorphisms in tumor necrosis factor (TNF) and TNF receptor genes and circulating TNF, soluble TNF receptor levels, and bone mineral density in postmenopausal Korean women. Menopause. 2009;16(5):1014-20.
Kim, H., Chun, S., Ku, S. Y., Suh, C. S., Choi, Y. M., & Kim, J. G. (2009). Association between polymorphisms in tumor necrosis factor (TNF) and TNF receptor genes and circulating TNF, soluble TNF receptor levels, and bone mineral density in postmenopausal Korean women. Menopause (New York, N.Y.), 16(5), 1014-20. https://doi.org/10.1097/gme.0b013e3181a039c8
Kim H, et al. Association Between Polymorphisms in Tumor Necrosis Factor (TNF) and TNF Receptor Genes and Circulating TNF, Soluble TNF Receptor Levels, and Bone Mineral Density in Postmenopausal Korean Women. Menopause. 2009 Sep-Oct;16(5):1014-20. PubMed PMID: 19369902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between polymorphisms in tumor necrosis factor (TNF) and TNF receptor genes and circulating TNF, soluble TNF receptor levels, and bone mineral density in postmenopausal Korean women. AU - Kim,Hoon, AU - Chun,Sungwook, AU - Ku,Seung Yup, AU - Suh,Chang Suk, AU - Choi,Young Min, AU - Kim,Jung Gu, PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2009/12/16/medline SP - 1014 EP - 20 JF - Menopause (New York, N.Y.) JO - Menopause VL - 16 IS - 5 N2 - OBJECTIVE: The aim of the present study was to investigate the relationship of polymorphisms in the tumor necrosis factor (TNF)-alpha, TNF-beta, and TNF receptor (TNFR) genes to circulating TNF, soluble TNFR (sTNFR) levels, and bone mineral density (BMD) in women. METHODS: The TNF-alpha G(-308)A, C(-857)T, C(-863)A, T(-1031)C, TNF-beta A252G, TNFRI A36G, TNFRII T676G, A1663G, A1668G, and C1690T polymorphisms were analyzed in 377 postmenopausal Korean women. The levels of serum TNF-alpha, TNF-beta, sTNFRI, sTNFRII, and bone turnover markers were measured. BMD was examined by dual energy x-ray absorptiometry. RESULTS: After adjustment for age, body mass index, and years since menopause, no significant differences in BMD of the lumbar spine and femoral neck and serum levels of bone turnover markers were detected, according to single polymorphisms in TNF and TNFR genes and combined polymorphisms. However, the frequencies of the TT genotype of TNF-alpha T(-1031)C polymorphism, the non-AA genotype of TNF-beta A252G polymorphism, and the GG genotype of TNFRII A1663G polymorphism were significantly higher in osteoporotic women than in women with normal BMD, respectively (P < 0.05). The TNFRII T676G polymorphism affected the serum sTNFRI and sTNFRII levels. The serum sTNFRII levels in the CC genotype of TNFRII C1690T polymorphism were the highest, with a G or C allele dose effect, and the TNFRII G676C/C1690T haplotype genotype also affected serum sTNFRII levels. CONCLUSIONS: TNF-alpha T(-1031)C, TNF-beta A252G, and TNFRII A1663G polymorphisms may be genetic factors for osteoporosis in Korean postmenopausal women, and the TNFRII T676G and C1690T polymorphisms and their combined polymorphism affected serum sTNFRII levels. The TNFRII T676G polymorphism also affected the serum sTNFRI levels. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/19369902/Association_between_polymorphisms_in_tumor_necrosis_factor__TNF__and_TNF_receptor_genes_and_circulating_TNF_soluble_TNF_receptor_levels_and_bone_mineral_density_in_postmenopausal_Korean_women_ L2 - http://dx.doi.org/10.1097/gme.0b013e3181a039c8 DB - PRIME DP - Unbound Medicine ER -