Tags

Type your tag names separated by a space and hit enter

Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants?
Free Radic Res 2009; 43(6):533-7FR

Abstract

It was previously hypothesized that serum gamma-glutamyltransferase (GGT) within its reference range predicts various clinical outcomes as a sensitive marker of oxidative stress in humans. This study further hypothesizes that serum GGT can mark exposure to various environmental pollutants, based both on recent epidemiological findings and on well-established biochemical features of cellular GGT. Cellular GGT is a prerequisite for metabolism of GSH conjugates that detoxify xenobiotics to mercapturic acid. Under this concept, serum GGT may increase with increasing exposure to environmental pollutants which need to be conjugated to GSH. Supporting this concept, it was recently reported that serum GGT within its reference range was linearly associated with important environmental pollutants, including lead, cadmium, dioxin and organochlorine pesticides. As a marker of the amount of conjugated xenobiotics, recent epidemiological findings about serum GGT imply the possibility of harmful effects of various environmental pollutants at background levels currently regarded as safe.

Authors+Show Affiliations

Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. lee_dh@knu.ac.krNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19370474

Citation

Lee, Duk-Hee, and David R. Jacobs. "Is Serum Gamma-glutamyltransferase a Marker of Exposure to Various Environmental Pollutants?" Free Radical Research, vol. 43, no. 6, 2009, pp. 533-7.
Lee DH, Jacobs DR. Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants? Free Radic Res. 2009;43(6):533-7.
Lee, D. H., & Jacobs, D. R. (2009). Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants? Free Radical Research, 43(6), pp. 533-7. doi:10.1080/10715760902893324.
Lee DH, Jacobs DR. Is Serum Gamma-glutamyltransferase a Marker of Exposure to Various Environmental Pollutants. Free Radic Res. 2009;43(6):533-7. PubMed PMID: 19370474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants? AU - Lee,Duk-Hee, AU - Jacobs,David R,Jr PY - 2009/4/17/entrez PY - 2009/4/17/pubmed PY - 2009/8/20/medline SP - 533 EP - 7 JF - Free radical research JO - Free Radic. Res. VL - 43 IS - 6 N2 - It was previously hypothesized that serum gamma-glutamyltransferase (GGT) within its reference range predicts various clinical outcomes as a sensitive marker of oxidative stress in humans. This study further hypothesizes that serum GGT can mark exposure to various environmental pollutants, based both on recent epidemiological findings and on well-established biochemical features of cellular GGT. Cellular GGT is a prerequisite for metabolism of GSH conjugates that detoxify xenobiotics to mercapturic acid. Under this concept, serum GGT may increase with increasing exposure to environmental pollutants which need to be conjugated to GSH. Supporting this concept, it was recently reported that serum GGT within its reference range was linearly associated with important environmental pollutants, including lead, cadmium, dioxin and organochlorine pesticides. As a marker of the amount of conjugated xenobiotics, recent epidemiological findings about serum GGT imply the possibility of harmful effects of various environmental pollutants at background levels currently regarded as safe. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/19370474/Is_serum_gamma_glutamyltransferase_a_marker_of_exposure_to_various_environmental_pollutants L2 - http://www.tandfonline.com/doi/full/10.1080/10715760902893324 DB - PRIME DP - Unbound Medicine ER -